{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:54:51Z","timestamp":1760385291992,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175039"],"award-info":[{"award-number":["175039"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Streptococcus pneumoniae is one of the leading causes of\n   bacterial meningitis and sepsis. Invasive pneumococcal disease is a\n   significant medical problem worldwide, particularly in children, due to a\n   huge increase of pneumococcal resistance to antibiotics. Objective. The aim\n   of the study was to investigate the antimicrobial susceptibility pattern of\n   invasive pneumococcal isolates, as well as to determine whether decreased S.\n   pneumoniae susceptibility to antibiotics was related to a particular\n   serotype. Methods. Antimicrobial susceptibility to 19 antibiotics was\n   determined in 58 invasive pneumococcal strains that were collected from seven\n   regional centers during the period July 2009 to February 2011 in the National\n   Reference Laboratory for streptococci and pneumococci. Results. The overall\n   nonsusceptibility rate to penicillin was detected in 34% of pneumococcal\n   isolates and to erythromycin in 36%. Higher resistance rates were observed\n   among children than among adults. Penicillin resistance rate was 65% in\n   children versus 22% in adults, while erythromycin nonsusceptibility rate was\n   47% in children versus 32% in adults. Co-resistance to penicillin and\n   erythromycin was detected in 21% strains, mostly isolated from children.\n   Multiresistance was found in one third of isolates. All strains were\n   susceptible to vancomycin, linezolid, fluoroquinolones, telithromycin and\n   rifampicin, while 23 (40%) isolates were susceptible to all tested\n   antibiotics. The most common resistant serotypes were 19F and 14. Conclusion.\n   The study has revealed that penicillin and macrolide resistance among\n   invasive pneumococcal isolates is very high in Serbia. This emphasizes the\n   need for continuous monitoring for invasive pneumococcal disease to document\n   the serotype distribution and antimicrobial susceptibility pattern.<\/jats:p>","DOI":"10.2298\/sarh1302048g","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T10:28:16Z","timestamp":1366799296000},"page":"48-53","source":"Crossref","is-referenced-by-count":5,"title":["Invasive isolates of Streptococcus pneumoniae in Serbia: Antimicrobial susceptibility and serotypes"],"prefix":"10.2298","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-2776","authenticated-orcid":false,"given":"Ina","family":"Gajic","sequence":"first","affiliation":[{"name":"Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Mijac","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lazar","family":"Ranin","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Andjelkovic","sequence":"additional","affiliation":[{"name":"Klini\u010dko-bolni\u010dki centar \u201eBe\u017eanijska kosa\u201c, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"Radicevic","sequence":"additional","affiliation":[{"name":"Klini\u010dko-bolni\u010dki centar \u201eBe\u017eanijska kosa\u201c, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Opavski","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:33:02Z","timestamp":1685356382000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791302048G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1302048g","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2013]]}}}