{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:48:25Z","timestamp":1773323305598,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"3-4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>It has been shown that the loss of regulatory function by deple? + Regulatory\n   T cells (Treg) represent a subset of CD4 T cells whose function is to\n   suppress immune responses. Treg lymphocytes can be divided into two subsets:\n   natural nTreg lymphocytes that are developed in the thymus and inducible\n   iTreg lymphocytes, which originate from conventional T lymphocytes on the\n   periphery. The majority of Treg lymphocytes express high levels of\n   interleukin?2 (IL?2) receptor ? chain (CD25) and transcription factor FoxP3\n   (critical for the development and suppressor activity of iTreg lymphocytes).\n   Cancer cells can modulate anti?tumor immune response indirectly, through the\n   activation of Treg lymphocytes. tion of tumor?induced Treg lymphocytes may\n   enhance effectors response, resulting in tumor rejection, while the increased\n   number of Treg lymphocytes effectively prevents tumor destruction. nTreg\n   lymphocytes express increasingly CTLA?4 and membrane? bound TGF??, which\n   inhibits cytokine production and responses of effectors lymphocytes. iTreg\n   lymphocytes secrete immunosuppressive cytokines such as IL?10 and TGF??. Treg\n   lymphocytes represent one of important obstruction in anti?tumor immunity.<\/jats:p>","DOI":"10.2298\/sarh1304262r","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T13:02:31Z","timestamp":1369227751000},"page":"262-267","source":"Crossref","is-referenced-by-count":4,"title":["The role of regulatory T cells in the modulation of anti-tumor immune response"],"prefix":"10.2298","volume":"141","author":[{"suffix":"D.","given":"Gordana","family":"Radosavljevic","sequence":"first","affiliation":[{"name":"Medicinski fakultet, Centar za molekulska istra\u017eivanja, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1169-2378","authenticated-orcid":false,"suffix":"P.","given":"Ivan","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Centar za molekulska istra\u017eivanja, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-040X","authenticated-orcid":false,"suffix":"V.","given":"Tatjana","family":"Kanjevac","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Centar za molekulska istra\u017eivanja, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-3490","authenticated-orcid":false,"suffix":"N.","given":"Nebojsa","family":"Arsenijevic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Centar za molekulska istra\u017eivanja, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:33:17Z","timestamp":1685356397000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791304262R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1304262r","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}