{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:09:15Z","timestamp":1685419755338},"reference-count":0,"publisher":"National Library of Serbia","issue":"5-6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Thirty to 50% of patients with chronic hepatitis C (CHC) have\n   one or more extrahepatic manifestations (EHMs) of hepatitis C virus (HCV)\n   infection. Objective. The aim of this study was to evaluate the frequency of\n   EHMs and to investigate the efficacy of pegylated interferon (Peg?IFN)???2a\n   plus ribavirin therapy in patients with HCV?related EHMs. Methods. The study\n   included 280 patients suffering from CHC and treated with Peg?IFN???2a and\n   ribavirin. The patients were divided in two groups according to presence or\n   absence of EHMs. We evaluated virological response to antiviral therapy.\n   Results. One or more EHMs were found among 27.9% of patients. Most frequently\n   they had rheumatoid factor in serum (12.5%), organ?nonspecific antibodies ANA\n   and AGMA (12.4%), thyroid hormone disorders (9.3%), vasculitis (5.7%),\n   diabetes mellitus (4.65%), glomerulonephritis (0.71%), and porphyria cutanea\n   tarda (0.36%). Among the patients with EHMs there was 52.6% of females vs.\n   30.2% of females in the group of patients without EHMs (p=0.001). HCV\n   genotypes 1 and 4 had 85.9% patients with EHMs vs. 58.4% of patients without\n   EHMs (p=0.000). Progressive fibrosis and cirrhosis were more frequently\n   recorded in the EHM group of patients (32% vs. 23.2%), but without\n   statistically significant difference (p=0.532). Serious adverse events of\n   Peg?IFN???2a and ribavirin were statistically significantly recorded among\n   the patients with EHMs (46.1% vs. 12.9%; p=0.000). Sustained virological\n   response among the patients with and without EHMs rated 56.9% and 70.8%\n   respectively (p=0.125). Conclusion. Patients with CHC and EHMs treated with\n   combined Peg?IFN???2a and ribavirin experience handling difficulties, more\n   often have serious adverse events, while successful outcome is achieved in\n   about 50% of patients.<\/jats:p>","DOI":"10.2298\/sarh1306320f","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T06:41:19Z","timestamp":1374216079000},"page":"320-324","source":"Crossref","is-referenced-by-count":0,"title":["Extrahepatic manifestations of chronic hepatitis C and their influence on response to treatment with Pegylated interferon alfa-2a and ribavirin"],"prefix":"10.2298","volume":"141","author":[{"given":"Milotka","family":"Fabri","sequence":"first","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Ruzic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajana","family":"Lendak","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomislav","family":"Preveden","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Fabri","sequence":"additional","affiliation":[{"name":"Institut za zdravstvenu za\u0161titu dece i omladine Vojvodine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedrana","family":"Petric","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za infektivne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:33:19Z","timestamp":1685356399000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791306320F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1306320f","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}