{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:14:04Z","timestamp":1773288844537,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"5-6","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Statins have similar side effects that do not always occur at\n   the same rate among the various statins. We present a case of\n   simvastatin-induced muscle toxicity that disappeared when pravastatin was\n   substituted for the original drug. Case Outline. A 74-year-old male, a\n   nonsmoker, complained of severe nocturnal leg cramps. The patient also\n   complained that similar painful cramping occurred when he walked rapidly or\n   jogged. Because some components of his lipid panel exceeded the ?desirable?\n   range, and as he had a history of myocardial infarction, his family physician\n   prescribed simvastatin (40 mg\/day). The patient had taken this medication for\n   the past eight years. The painful nocturnal episodes started two years ago\n   and affected either one or the other leg. Four months ago we discontinued his\n   simvastatin and prescribed pravastatin (80 mg\/day). At a follow-up visit six\n   weeks later, the patient reported that his leg pains at night and the pain\n   experienced after brisk walking had disappeared. Four months after the\n   substitution of pravastatin for simvastatin, the patient reported that his\n   complete lack of symptoms had continued. Conclusion. These painful muscle\n   cramps were probably caused by an inadequate vascular supply to the calf and\n   foot muscles. Perhaps a combination of advanced age and atherosclerotic\n   changes created a predisposition for the simvastatin-induced leg cramps.\n   Pravastatin differs from simvastatin in several ways. It is not metabolized\n   by cytochrome P450 (CYP) 3A4 oxidases, and thus is not influenced by CYP 3A4\n   inhibitors like simvastatin. Also, simvastatin is associated with\n   single-nucleotide polymorphisms located within the SLCO1B1 gene on the\n   chromosome 12 and established myopathy, while pravastatin lacks this\n   association. These differences may contribute to increased tolerance to\n   pravastatin in this particular case.<\/jats:p>","DOI":"10.2298\/sarh1306387s","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T06:41:19Z","timestamp":1374216079000},"page":"387-389","source":"Crossref","is-referenced-by-count":4,"title":["Simvastatin-induced nocturnal leg pain disappears with pravastatin substitution"],"prefix":"10.2298","volume":"141","author":[{"given":"Natasa","family":"Stojakovic","sequence":"first","affiliation":[{"name":"Univerzitet u Banjaluci, Medicinski fakultet, Katedra za farmakologiju, toksikologiju i klini\u010dku farmakologiju, Banjaluka, Republika Srpska, Bosna i Hercegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajko","family":"Igic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology, and Clinical Pharmacology, Medical School, University of Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina + Department of Anesthesiology and Pain Management, John Stoger Hospital of Cook County, Ch"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:33:25Z","timestamp":1685356405000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791306387S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1306387s","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}