{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:18:23Z","timestamp":1777731503177,"version":"3.51.4"},"reference-count":0,"publisher":"National Library of Serbia","issue":"7-8","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Combining two medications in one bottle may improve compliance\n   by reducing the time required to administer drops and the frequency of the\n   total number of medication bottles. Objective. To compare the efficacy of\n   reduced intraocular pressure (IOP) and safety of fixed combination travoprost\n   0.004%\/timolol 0.5% vs. fixed combination dorzolamide 2%\/timolol 0.5% in\n   patients with primary open-angle glaucoma or ocular hypertension. Methods.\n   Prospective randomized clinical study included 60 patients divided into 2\n   groups. Follow-up was done at day 14 and 45 and month 3. IOP measurements\n   were taken at each follow-up examination at 8 am, 10 am and 4 pm. Results.\n   Both fixed combinations reduced IOP significantly compared to initial values\n   at all follow-ups (p&lt;0.001). Mean pooled IOP at all visits and time points\n   was slightly lower in the travoprost\/timolol group compared with the\n   dorzolamide\/timolol group (16.13 mmHg vs. 16.15 mmHg). Mean IOP reduction\n   from baseline ranged from -7.46 mmHg to -9.92 mmHg in the travoprost\/timolol\n   group and from -6.93 mmHg to -8.93 mmHg for the dorzolamide\/timolol group.\n   Mean (?standard error of the mean) reduction in diurnal IOP from baseline to\n   3rd month was 8.96?2.79 in the travoprost\/timolol group versus 8.07?2.91 in\n   patients receiving dorzolamide\/timolol fixed combination (p=0.196). The most\n   frequent treatment-related adverse events were conjunctival hyperemia in the\n   travoprost\/timolol group, and dry eye and foreign body sensation in the\n   dorzolamide\/timolol group. Conclusion. Travoprost\/timolol fixed combination\n   was slightly more effective than dorzolamide\/timolol fixed combination in\n   reducing mean diurnal IOP. Travoprost\/timolol group resulted in an IOP\n   reduction for up to 1.07 mmHg higher than dorzolamide\/timolol group. Both\n   fixed combinations were well tolerated and safe.<\/jats:p>","DOI":"10.2298\/sarh1308441b","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T09:34:07Z","timestamp":1383730447000},"page":"441-446","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the efficacy and safety of fixed combination travoprost\/timolol and dorzolamide\/timolol in patients with primary open-angle glaucoma and ocular hypertension"],"prefix":"10.2298","volume":"141","author":[{"given":"Nikola","family":"Babic","sequence":"first","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za o\u010dne bolesti, Novi Sad + Medicinski fakultet, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-0703","authenticated-orcid":false,"given":"Veljko","family":"Andreic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Vojvodine, Klinika za o\u010dne bolesti, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Miljkovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Eye Clinic, Novi Sad + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desanka","family":"Grkovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Eye Clinic, Novi Sad + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4259-0101","authenticated-orcid":false,"given":"Predrag","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Clinical Center, Eye Clinic, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:33:28Z","timestamp":1685356408000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791308441B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1308441b","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}