{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:37:38Z","timestamp":1781951858181,"version":"3.54.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Introduction. The multiple endocrine neoplasia type 2A (MEN 2A) syndrome,\n   comprising medullary thyroid carcinoma (MTC), pheochromocytoma and primary\n   hyperparathyroidism (PHPT) is most frequently caused by codon 634 activating\n   mutations of the RET (rearranged during transfection) proto-oncogene on\n   chromosome 10. For this codon-mutation carriers, earlier thyroidectomy\n   (before the age of 5 years) would be advantageous in limiting the potential\n   for the development of MTC as well as parathyroid adenomas. Case Outline.\n   This is a case report of 3-year-old boy from the MEN 2A family (the boy?s\n   father and grandmother and paternal aunt) in which cysteine substitutes for\n   phenylalanine at codon 634 in exon 11 of the RET proto-oncogene, who\n   underwent thyroidectomy solely on the basis of genetic information. A boy had\n   no thyromegaly, thyroidal irregularities or lymphadenopathy and no\n   abnormality on the neck ultrasound examination. The pathology finding of\n   thyroid gland was negative for MTC. Two years after total thyroidectomy,\n   5-year-old boy is healthy with permanent thyroxine replacement. His serum\n   calcitonin level is &lt;2 pg\/ml (normal &lt;13 pg\/ml), has normal serum calcium and\n   parathyroid hormone levels and negative urinary catecholamines. Long-term\n   follow-up of this patient is required to determine whether very early\n   thyroidectomy improves the long-term outcome of PHPT. Conclusion. Children\n   with familial antecedents of MEN 2A should be genetically studied for the\n   purpose of determining the risk of MTC and assessing the possibilities of\n   making prophylactic thyroidectomy before the age of 5 years.<\/jats:p>","DOI":"10.2298\/sarh1402072j","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T11:10:21Z","timestamp":1397473821000},"page":"72-74","source":"Crossref","is-referenced-by-count":2,"title":["Prophylactic thyroidectomy for asymptomatic 3-year-old boy with positive multiple endocrine neoplasia type 2A mutation (codon 634)"],"prefix":"10.2298","volume":"142","author":[{"suffix":"D.","given":"Maja","family":"Jesic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milina","family":"Tancic-Gajic","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"M.","given":"Milos","family":"Jesic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-6751","authenticated-orcid":false,"given":"Vladan","family":"Zivaljevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Center for Endocrine Surgery, Clinical Center of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvija","family":"Sajic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Vujovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetozar","family":"Damjanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:34:17Z","timestamp":1685356457000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791402072J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1402072j","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}