{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:10:37Z","timestamp":1788869437207,"version":"build-2803163510"},"reference-count":0,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175085"],"award-info":[{"award-number":["175085"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Introduction. Post-transplant lymphoproliferative disorder (PTLD) is a\n   heterogeneous group of diseases, characterized by abnormal lymphoid\n   proliferation following transplantation. It is a disease of the\n   immunosuppressed state, and its occurrence is mostly associated with the use\n   of T-cell depleting agents, and also intensification of immunosuppressive\n   regimens. In the majority of cases, PTLD is a consequence of Epstein-Barr\n   virus (EBV) infection and is a B-cell hyperplasia with CD-20 positive\n   lymphocytes. The 2008 World Health Organization classification for lymphoid\n   malignancies divides PTLD into four major categories: early lesions,\n   polymorphic PTLD, monomorphic PTLD and Hodgkin PTLD. The treatment and\n   prognosis depend on histology. The cornerstone of PTLD therapy includes\n   reduction\/withdrawal of immunosuppression, monoclonal anti CD-20 antibody\n   (rituximab) and chemotherapy. Outline of Cases. We reported here our\n   experiences with three patients, two girls aged 7.5 and 15 and a 16-year old\n   boy. They had different organ involvement: brain, combined spleen-liver and\n   intestines, respectively. Even though EBV was a trigger of lymphoid\n   proliferation as it was confirmed by histopathology or in cerebrospinal\n   fluid, qualitative EBV-PCR was positive only in one patient at disease\n   presentation. Reduction of immunosuppression therapy was applied in treatment\n   of all three patients, while two of them received rituximab and ganciclovir.\n   They had an excellent outcome besides many difficulties in diagnosis and\n   management of disease. Conclusion. Qualitative EBV-PCR is not useful marker\n   in pediatric transplant recipients. Our suggestion is that patients with the\n   risk factors like T-cell depleting agents, immunosuppressant protocol or\n   increasing immunosuppressive therapy and EBV miss-match with donor must be\n   more accurately monitored with quantitative EBV PCR.<\/jats:p>","DOI":"10.2298\/sarh1402083s","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T07:10:21Z","timestamp":1397459421000},"page":"83-88","source":"Crossref","is-referenced-by-count":4,"title":["Post-transplant lymphoproliferative disorder: Case reports of three children with kidney transplant"],"prefix":"10.2298","volume":"142","author":[{"given":"Brankica","family":"Spasojevic-Dimitrijeva","sequence":"first","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Peco-Antic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-8890","authenticated-orcid":false,"given":"Dusan","family":"Paripovic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divna","family":"Kruscic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Krstic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Urology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Cupic","sequence":"additional","affiliation":[{"name":"Urology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Cvetkovic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Milosevski-Lomic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-4884","authenticated-orcid":false,"given":"Mirjana","family":"Kostic","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Children\u2019s Hospital, Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T06:34:18Z","timestamp":1685342058000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791402083S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1402083s","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}