{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:21:40Z","timestamp":1764174100516},"reference-count":0,"publisher":"National Library of Serbia","issue":"5-6","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Introduction. Bernard-Soulier syndrome (BSS) is a rare inherited bleeding\n   disorder characterized by giant platelets thrombocytopenia e prolonged\n   bleeding timee frequent hemorrhages with considerable morbidity. Data on the\n   outcome of pregnancy and gynecological intervention in BSS are rare and there\n   are no general therapeutic recommendations. Cases Outline. We report two\n   cases of BSS. In the first case a 29-year-old patient with BSS was admitted\n   in 8 weeks of gestation. The diagnosis of BSS was made on the basis of\n   prolonged bleeding time, giant-platelets thrombocytopenia, and absent\n   ristocetin-induced platelet aggregation. In 38 week of gestation Cesarean\n   section, with platelets transfusion preparation, was performed. Obstetric\n   intervention passed without complication. Postoperative course was\n   complicated with a three-week vaginal bleeding resistant to platelet\n   transfusion. Neonate platelet count was normal. Our second case was a\n   28-year-old patient with BSS, hospitalized for ovarial tumor surgery. The\n   patient was prepared for the intervention with platelets transfusion. The\n   surgery was uncomplicated, but on the second postoperative day a massive\n   vaginal bleeding, resistant to the platelet transfusion, developed. Bleeding\n   control was achieved with activated recombinant factor VII. Twelve hours the\n   patient developed later hypertensive crisis with epileptic seizure due to\n   subarachnoid hemorrhage. Therapy was continued with platelet transfusion,\n   antihypertensive and antiedema drugs. PH examination of tumor tissue showed\n   hemorrhagic ovarial cyst. Conclusion. Obstretic and gynecological\n   intervention in women with BSS may be associated with a life-threatening\n   bleeding thus requiring a multidisciplinary approach with adequate\n   preparation. Because of the limited data in the literature, it is not\n   possible to provide firm management recommendations and each case should be\n   managed individually.<\/jats:p>","DOI":"10.2298\/sarh1406351m","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T13:24:41Z","timestamp":1404825881000},"page":"351-355","source":"Crossref","is-referenced-by-count":5,"title":["Obstetric and gynecological intervention in women with Bernard-Soulier syndrome: Report of two cases"],"prefix":"10.2298","volume":"142","author":[{"given":"Mirjana","family":"Mitrovic","sequence":"first","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Elezovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Hematology, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Predrag","family":"Miljic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Hematology, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Antic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Hematology, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:34:42Z","timestamp":1685356482000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791406351M"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1406351m","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}