{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:10:42Z","timestamp":1685419842164},"reference-count":0,"publisher":"National Library of Serbia","issue":"9-10","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Introduction. Acute hepatitis C most frequently develops after parenteral\n   infection of hepatitis C virus. The disease often develops into chronic\n   infection, although it can resolve spontaneously. Interferon alpha (INF-?) is\n   used in therapy, but still without precise treatment recommendations.\n   Objective. The aim was to present characteristics of patients with acute\n   hepatitis C and to assess effectiveness of using recombinant INF-? in\n   therapy. Methods. Total of 55 patients with acute hepatitis C, hospitalized\n   at the Clinic for Infectious Diseases in Belgrade from January 2005 to\n   December 2012 were enrolled in this study. Forty-one patients were under\n   follow-up over six months for evaluation of the development of the disease\n   into a chronic infection and effectiveness of treatment with INF-?. Results.\n   Eighty percent of patients were male of average age 29.6?8.6 years; in 61.8%\n   patients intravenous drug abuse was determined as risk factor. Thirty\n   patients (54.1%) had no symptoms and 38.2% were icteric. Acute hepatitis C\n   spontaneously resolved in 33.3% patients, while in the treated group 79.6% of\n   patients completely recovered (p=0.006). Treatment success was 92.9% in the\n   group of patients who started with treatment before the 45th day of disease,\n   while in the patients who started treatment later the success rated 58.3%\n   (p=0.037). Conclusion. Acute hepatitis C is most common in young male adults\n   infected via injection drug abuse. The use of INF-? is effective in the\n   treatment of the disease, and success of the treatment is more probable if\n   treatment is started before the 45th day.<\/jats:p>","DOI":"10.2298\/sarh1410564m","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T12:40:28Z","timestamp":1415104828000},"page":"564-571","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of acute hepatitis C"],"prefix":"10.2298","volume":"142","author":[{"given":"Nikola","family":"Mitrovic","sequence":"first","affiliation":[{"name":"Clinical Center of Serbia, Clinic for Infectious and Tropical Disease, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasa","family":"Popovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic for Infectious and Tropical Disease, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Delic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic for Infectious and Tropical Disease, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Stojkovic-Svirtlih","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic for Infectious and Tropical Disease, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:35:02Z","timestamp":1685356502000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791410564M"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1410564m","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}