{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:10:43Z","timestamp":1685419843981},"reference-count":0,"publisher":"National Library of Serbia","issue":"9-10","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Despite recent advances in the management of children with chronic renal\n   disease (CRD), growth retardation remains its most visible comorbid\n   condition. Growth retardation has adverse impact on morbidity and mortality\n   rates, quality of life and education, and in adult patients on job family\n   life, and independent leaving accomodation. Pathophysiology of impaired\n   growth in CRD is complex and still not fully understood. The following\n   complications are: anorexia, malnutrition, inflammation, decreased residual\n   renal function, dialysis frequency and adequacy, renal anemia, metabolic\n   acidosis, fluid\/electrolyte imbalance, renal osteodistrophy, growth hormone\n   (GH) and insulin-like growth factor -1 (IGF-1) resistance. Malnutrition is\n   most frequent and most important factor contributing to the degree of growth\n   retardation in infancy. The degree of renal dysfunction is the major\n   determinant of variability in growth from third year of age until puberty\n   onset, while in puberty hypergonadotropic hypogonadism has negative effect.\n   The main factors that influence growth after renal transplantation are the\n   age of the recipient and glucocorticoid drugs dosage with negative effect and\n   allograft function with positive effect. In order to improve growth in\n   children with CRD it is necessary to include: diet with optimal caloric\n   intake, correction of fluid\/ electrolyte imbalance, correction of acidosis,\n   renal osteodistrophy and anemia. If growth velocity is insufficient to\n   normalize growth, it is necessary to start recombinant human GH (rhGH)\n   therapy at 0.05 mg\/kg per day (0.35 mg\/kg per week or 28 IU\/m2 per week)\n   administered by subcutaneous injection.<\/jats:p>","DOI":"10.2298\/sarh1410614p","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T12:40:28Z","timestamp":1415104828000},"page":"614-620","source":"Crossref","is-referenced-by-count":1,"title":["Growth retardation in children with chronic renal disease"],"prefix":"10.2298","volume":"142","author":[{"given":"Amira","family":"Peco-Antic","sequence":"first","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade + School of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brankica","family":"Spasojevic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:35:07Z","timestamp":1685356507000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791410614P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1410614p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}