{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:48:51Z","timestamp":1780512531230,"version":"3.54.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Introduction. X-linked adrenal hypoplasia congenita (AHC) is a rare cause of\n   adrenocortical insufficiency. Early postnatal diagnosis may prevent severe\n   hypoglycemia, Addisonian crises and death. Low maternal estriol (E3) levels\n   in the second trimester of pregnancy could indicate the possibility that the\n   fetus suffers from a disorder that causes adrenal insufficiency. Suspicion\n   is based on the fact that E3 originates from dehydroepiandrosterone (DHEA)\n   synthesized in the fetal adrenals. In case of adrenal insufficiency, the\n   impaired production of fetal DHEA leads to a subsequent reduction of E3\n   concentrations in maternal serum. There are only a few reports of AHC\n   suspected prenatally due to low maternal E3 levels. Case Outline. We\n   describe two brothers with adrenal insufficiency due to AHC. The older\n   brother was admitted to the hospital at the age of 33 days due to failure to\n   thrive, vomiting, and dehydration. Genetic analysis revealed a hemizygous\n   mutation in DAX-1 gene, thus confirming the diagnosis of ACH. The same\n   mutation was detected in his mother. In the second pregnancy, E3\n   concentrations were determined from maternal serum. Estriol levels during\n   the second trimester were extremely low suggesting the diagnosis of AHC. The\n   diagnosis was confirmed during the neonatal period by genetic testing, and\n   replacement therapy was started at the age of 10 days. This boy never\n   experienced an adverse episode such as hypoglycemia or adrenal crises.\n   Conclusion. Since determination of E3 is a simple, sensitive, noninvasive\n   and cheap method, its use as an obligatory prenatal screening test should be\n   accepted as a standard practice in Serbia.<\/jats:p>","DOI":"10.2298\/sarh1412728d","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T11:58:57Z","timestamp":1420545537000},"page":"728-731","source":"Crossref","is-referenced-by-count":8,"title":["Low estriol levels in the maternal marker screen as a predictor of X-linked adrenal hypoplasia congenita: Case report"],"prefix":"10.2298","volume":"142","author":[{"given":"Jasmina","family":"Durkovic","sequence":"first","affiliation":[{"name":"Department of Genetics, Hospital Subotica, Subotica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Milenkovic","sequence":"additional","affiliation":[{"name":"Institute for Mother and Child Health Care of Serbia \u201cDr Vukan \u010cupi\u0107\u201d, Department of Endocrinology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Krone","sequence":"additional","affiliation":[{"name":"University of Birmingham, School of Clinical and Experimental Medicine, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Parajes","sequence":"additional","affiliation":[{"name":"University of Birmingham, School of Clinical and Experimental Medicine, Birmingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Mandic","sequence":"additional","affiliation":[{"name":"MegaLab Biochemical Laboratory, Subotica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:56:12Z","timestamp":1685354172000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791412728D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1412728d","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}