{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:22:12Z","timestamp":1764174132620,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Nasal polyposis is a chronic inflammatory disease of the nasal and paranasal\n   sinuses mucosa, characterized by prolaps of edematous mucosa, most commonly\n   from the area of anterior ethmoid. The mean histological characteristics are\n   proliferation of pseudostratified respiratory epithelium, thickening of the\n   basement membrane, focal fibrosis and eosinophilic and lymphocytic\n   infiltration of the lamina propria. Although etiology is unknown, two\n   hypotheses are dominant among the scientists: ?hypothesis of staphylococcal\n   superantigens? and ?hypothesis of immune barrier dysfunction?. Although we\n   have not yet achieved a full understanding of the precise mechanisms\n   underlying the pathogenesis of this disease, it is known that nasal polyposis\n   is associated with intensive chronic inflammation, followed by dysregulation\n   of chemotaxis, migration, activation and function of eosinophils. A great\n   number of cytokines, chemokines, and adhesion molecules are involved in the\n   regulation of these complex mechanisms. After activation, eosinophils produce\n   and release enzymes, which can lead to the damage of mucosa and tissue\n   remodeling. Hyperactive eosinophils release a new amount of chemokines and\n   cytokines, attracting new eosinophils into the site of inflammation, and may\n   cause the persistence of chronic inflammation.<\/jats:p>","DOI":"10.2298\/sarh1412740p","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T11:58:57Z","timestamp":1420545537000},"page":"740-746","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory mechanisms in nasal polyposis"],"prefix":"10.2298","volume":"142","author":[{"given":"Aleksandar","family":"Peric","sequence":"first","affiliation":[{"name":"University of Defense, Faculty of Medicine, Belgrade + Military Medical Academy, Department of Otorhinolaryngology, Rhinology Unit, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-3076","authenticated-orcid":false,"given":"Danilo","family":"Vojvodic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Defense, Belgrade + Military Medical Academy, Institute for Medical Research, Division of Clinical and Experimental Immunology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:56:14Z","timestamp":1685354174000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791412740P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1412740p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2014]]}}}