{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:39:07Z","timestamp":1740152347731,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"5-6","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["OI 175034"],"award-info":[{"award-number":["OI 175034"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. Acute leukemias treatment requires strong chemotherapy.\n   Patients that develop bone marrow aplasia become immunocompromised, thus\n   becoming liable to bacterial and fungal infections. Fungal infections caused\n   by Candida are frequent. Hepatosplenic candidiasis (HSC) is a frequent\n   consequence of invasive candidiasis which is clinically presented with\n   prolonged febrility unresponsive to antibiotics. Case Outline. A 53-year-old\n   patient with acute myeloid leukemia was submitted to standard chemotherapy\n   ?3+7? regimen (daunoblastine 80 mg i.v. on days 1 to 3, cytarabine 2?170 mg\n   i.v. during 7 days) and achieved complete remission. However, during\n   remission he developed febrility unresponsive to antibiotics. Computerised\n   tomography (CT) of the abdomen showed multiple hypodense lesions within the\n   liver and spleen. Haemocultures on fungi were negative. However,\n   seroconversion of biomarkers for invasive fungal infection (IFI) (Candida and\n   Aspergillus antigen\/Ag and antibody\/Ab) indicated possible HSC. Only high\n   positivity of anti-Candida IgG antibodies, positivity of mannan and CT\n   finding we regarded sufficient for the diagnosis and antimycotic therapy.\n   Three months of treatment with different antimycotics were necessary for\n   complete disappearance of both clinical symptoms and CT findings. Conclusion.\n   In patients with prolonged febrile neutropenia IFI has to be strongly\n   suspected. If imaging techniques show multiple hypodense lesions within liver\n   and spleen, HSC has to be taken seriously into consideration. We believe\n   that, along with CT finding, positive laboratory Candida biomarkers (mannan\n   and IgG antibodies) should be considered sufficient for ?probable HSC? and\n   commencement of antifungal therapy, which must be long enough, i.e. until\n   complete disappearance of clinical symptoms and CT findings are achieved.<\/jats:p>","DOI":"10.2298\/sarh1506341c","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T11:40:28Z","timestamp":1436355628000},"page":"341-345","source":"Crossref","is-referenced-by-count":1,"title":["Favorable outcome of hepatosplenic candidiasis in a patient with acute leukemia"],"prefix":"10.2298","volume":"143","author":[{"given":"Natasa","family":"Colovic","sequence":"first","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Arsic-Arsenijevic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + School of Medicine, Institute of Microbiology and Immunology, National Reference Medical Mycology Laboratory, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-4797","authenticated-orcid":false,"given":"Nada","family":"Suvajdzic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Djunic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica","family":"Tomin","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:56:59Z","timestamp":1685354219000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791506341C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1506341c","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2015]]}}}