{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:46:15Z","timestamp":1790948775874,"version":"4.1.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. The risk of metabolic abnormalities is greatly increased in\n   schizophrenic patients started on an atypical antipsychotic medication.\n   Patients with psychiatric disorders exceed mortality ranges resulting from,\n   among others, increased risk of cardiovascular events. Other factors\n   contributing to the development of metabolic syndrome include prolonged\n   duration of illness, increasing age, female sex and lifestyle factors.\n   Objective. This cross-sectional study was taken up to assess the prevalence\n   of the metabolic syndrome (MetS) in schizophrenic patients receiving\n   olanzapine monotherapy for at least six months and to determine the most\n   important risk factors associated with metabolic syndrome presence in these\n   patients. Methods. A total of 93 long term hospitalized schizophrenic\n   patients (71 men, 22 women), had a screening of the following: case-history\n   data, psychiatric scales, anthropometric measures, blood (fasting glucose,\n   lipid status, C-reactive protein - CRP) and urine samples (microalbuminuria).\n   Results. Prevalence of MetS according to International Diabetes Federation\n   criteria in our study was 34.4%. The multivariate analysis distinguished the\n   following significant predictors of MetS presence (in order of appearance):\n   data about diabetes mellitus in family history (p=0.002), body mass index &gt;25\n   kg\/m2 (p=0.002), hyperlipidemia in family history (p=0.008), and elevated CRP\n   value (p=0.042). Conclusion. High rate of MetS in patients treated with\n   olanzapine in this study exceeds MetS prevalence in general population. Among\n   observed parameters, our study pointed to several ?high risk? predictors\n   associated with MetS presence. Regular monitoring of cardiometabolic risk\n   factors is highly recommended. Positive heredity distress mentioned above may\n   direct a psychiatrist to prescribe some other drug than olanzapine in the\n   long term treatment of schizophrenia.<\/jats:p>","DOI":"10.2298\/sarh1512712p","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:25:51Z","timestamp":1453472751000},"page":"712-718","source":"Crossref","is-referenced-by-count":11,"title":["Long-term treatment with olanzapine in hospital conditions: Prevalence and predictors of the metabolic syndrome"],"prefix":"10.2298","volume":"143","author":[{"given":"Irena","family":"Popovic","sequence":"first","affiliation":[{"name":"Special Hospital for Mental Disorders Gornja Toponica, Ni\u0161"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Ravanic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-8828","authenticated-orcid":false,"given":"Slobodan","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-0608","authenticated-orcid":false,"given":"Dragan","family":"Milovanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-3488","authenticated-orcid":false,"given":"Marko","family":"Folic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Stanojevic","sequence":"additional","affiliation":[{"name":"Special Hospital for Mental Disorders Gornja Toponica, Ni\u0161"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milutin","family":"Nenadovic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department for Psychiatry, Kosovska Mitrovica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Ilic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:57:29Z","timestamp":1685354249000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791512712P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1512712p","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}