{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:41:15Z","timestamp":1760013675659,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["41004"],"award-info":[{"award-number":["41004"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. In patients with acute leukemias hemorrhage is the most\n   frequent problem. Vein thrombotic events may appear rarely but arterial\n   thromboses are exceptionally rare. We present a patient with acute leukemia\n   and bilateral deep leg vein thrombosis who developed an acute myocardial\n   infarction (AMI) during induction chemotherapy. The etiology and treatment of\n   AMI in patients with acute leukemia, which is a rare occurrence, is\n   discussed. Case Outline. In April of 2012 a 37-year-old male presented with\n   bilateral deep leg vein thrombosis and malaise. Laboratory data were as\n   follows: Hb 118 g\/L, WBC 354x109\/L (with 91% blasts in differential leukocyte\n   count), platelets 60?109\/L. Bone marrow aspirate and immunophenotype revealed\n   the presence of acute lymphoblastic leukemia. Cytogenetic analysis was as\n   follows: 46,XY,t(4;11)(q21:q23) [2]\/62-82,XY,t(4;11)[18]. Molecular analysis\n   showed MLL-AF4 rearrangement. The patient was on low molecular weight heparin\n   and combined chemotherapy according to protocol HyperCVAD. On day 10 after\n   chemotherapy he got chest pain. Three days later AMI was diagnosed (creatine\n   kinase 66 U\/L, CK-MB 13U\/L, troponin 1.19 ?g\/L). Electrocardiogram showed the\n   ST elevation in leads D1, D2, aVL, V5 and V6 and ?micro q? in D1. On\n   echocardiography, hypokinesia of the left ventricle and ejection fraction of\n   39% was found. After recovering from AMI and restoring left ventricle\n   ejection fraction to 59%, second course of HyperCVAD was given. The control\n   bone marrow aspirate showed 88% of blasts but with monoblastic appearance.\n   Flow cytometry confirmed a lineage switch from lymphoblasts to monoblasts. In\n   further course of the disease he was treated with a variety of\n   chemotherapeutic combinations without achieving remission. Eventually,\n   palliative chemotherapy was administered to reduce the bulk of blasts. He\n   died five months after the initial diagnosis. Conclusion. AMI in young adults\n   with acute leukemia is a very rare complication which may occur in patients\n   with very high white blood cell count in addition with presence of a CD56\n   adhesion molecule and other concomitant thrombophilic factors. The treatment\n   of AMI in patients with acute leukemias should include antiplatelet and\n   anticoagulant therapy, even with more aggressive methods depending on\n   patient?s age and clinical risk assessment.<\/jats:p>","DOI":"10.2298\/sarh1512734c","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:25:51Z","timestamp":1453472751000},"page":"734-738","source":"Crossref","is-referenced-by-count":5,"title":["Acute myocardial infarction during induction chemotherapy for acute MLL t(4;11) leukemia with lineage switch and extreme leukocytosis"],"prefix":"10.2298","volume":"143","author":[{"given":"Natasa","family":"Colovic","sequence":"first","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-7308","authenticated-orcid":false,"given":"Andrija","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Virijevic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Vidovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica","family":"Tomin","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Hematology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:57:31Z","timestamp":1685354251000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791512734C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1512734c","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2015]]}}}