{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T15:39:00Z","timestamp":1740152340220,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11-12","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["41004"],"award-info":[{"award-number":["41004"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. Hemophagocytic lymphohistiocytosis (HLH) is a severe\n   hyperinflammatory condition characterized by fever, cytopenias,\n   hepatosplenomegaly and hemophagocytosis. HLH may be primary or secondary to\n   infection, autoimmune disease or malignancy. Hypertriglyceridemia is a common\n   abnormality in HLH and one of the HLH-2004 diagnostic criteria. Case Outline.\n   We present an infant with severe hypotonia and hypoproteinemic edema who also\n   had extreme hypertriglyceridemia (21 mmol\/l) and was diagnosed with HLH based\n   on six of eight HLH- 2004 criteria (fever, hepatosplenomegaly, bicytopenia,\n   hypertriglyceridemia with hypofibrinogenemia, sIL-2R &gt; 2400 IU\/ml,\n   hemophagocytosis). The presence of IgM antibodies to Epstein-Barr virus and\n   cytomegalovirus indicated a probable infectious trigger. The child was cured\n   by the HLH-2004 protocol for secondary HLH (consisting of dexamethasone and\n   cyclosporine). He was also found to have low serum hydroxycobalamin levels,\n   promptly corrected upon hydroxycobalamin administration. Conclusion. The\n   presented case history underlines the need to ascertain the presence or\n   absence of each of the eight HLH-2004 criteria in any patient suspected to\n   suffer from HLH.<\/jats:p>","DOI":"10.2298\/sarh1512744d","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T14:25:51Z","timestamp":1453472751000},"page":"744-747","source":"Crossref","is-referenced-by-count":3,"title":["Extreme hypertriglyceridemia in an infant with hemophagocytic lymphohistiocytosis and hydroxycobalamin deficiency"],"prefix":"10.2298","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-4074","authenticated-orcid":false,"given":"Lidija","family":"Dokmanovic","sequence":"first","affiliation":[{"name":"School of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Krstovski","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Lazic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-0845","authenticated-orcid":false,"given":"Predrag","family":"Rodic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Milosevic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdja","family":"Jankovic","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Janic","sequence":"additional","affiliation":[{"name":"School of Medicine, Belgrade + University Children\u2019s Hospital, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:57:31Z","timestamp":1685354251000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791512744D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1512744d","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"type":"print","value":"0370-8179"},{"type":"electronic","value":"2406-0895"}],"subject":[],"published":{"date-parts":[[2015]]}}}