{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:44:20Z","timestamp":1778755460736,"version":"3.51.4"},"reference-count":0,"publisher":"National Library of Serbia","issue":"1-2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Srp Arh Celok Lek","SRP ARH CELOK LEK","SRP ARK CELOK LEK","SRPSKI ARHIV CELOKUP"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Introduction. Urban life is often followed by immune dysfunction and loss of\n   immune tolerance in the youngest children. Objective. The study aimed to\n   determine optimal time efficiency of a synbiotic (5.109 Lactobacillus\n   acidophilus Rosell-52, Bifidobacterium infantis Rosell-33, Bifidobacterium\n   bifidum Rosell-71) in controlling respiratory infections and wheezing\n   disease. Methods. We randomly selected a group of children younger than five\n   years, hospitalized earlier, and classified them into three groups. Results.\n   The incidence of respiratory infection before the study was once a month,\n   while after a threemonth supplementation with the synbiotic children rarely\n   suffered from respiratory infections, and the state was maintained after\n   six-month and nine-month supplementations with the synbiotic. The decreased\n   incidence of respiratory infections was followed by a falling incidence of\n   concomitant wheezing. A significant increase in tIgA serum was observed in\n   all groups for only three months, the increase being the highest in children\n   with recurrent respiratory infections accompanied by wheezing. After a\n   ninemonth administration of the synbiotic, total IgE serum was lower in all\n   groups of patients. Conclusion. The optimal duration of administration of\n   the synbiotic containing three probiotic cultures to provide effective\n   control of the frequency of respiratory infections was three months, and six\n   months were required to establish control of the frequency of wheezing. This\n   synbiotic is useful for immunomodulation in children and is well-tolerated\n   in young children.<\/jats:p>","DOI":"10.2298\/sarh1602038s","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T11:43:27Z","timestamp":1459165407000},"page":"38-45","source":"Crossref","is-referenced-by-count":9,"title":["Clinical trial\/experimental study (consort compliant): Optimal time period to achieve the effects on synbiotic-controlled wheezing and respiratory infections in young children"],"prefix":"10.2298","volume":"144","author":[{"given":"Andjelka","family":"Stojkovic","sequence":"first","affiliation":[{"name":"Clinical Center Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-1972","authenticated-orcid":false,"given":"Aleksandra","family":"Simovic","sequence":"additional","affiliation":[{"name":"Clinical Center Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"State University of Novi Pazar, Novi Pazar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragic","family":"Bankovic","sequence":"additional","affiliation":[{"name":"State University of Novi Pazar, Novi Pazar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-3733","authenticated-orcid":false,"given":"Mina","family":"Poskurica","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Srpski arhiv za celokupno lekarstvo"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T09:57:50Z","timestamp":1685354270000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0370-81791602038S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/sarh1602038s","relation":{},"ISSN":["0370-8179","2406-0895"],"issn-type":[{"value":"0370-8179","type":"print"},{"value":"2406-0895","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}