{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:05:57Z","timestamp":1685419557932},"reference-count":15,"publisher":"National Library of Serbia","issue":"4","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2005]]},"abstract":"<jats:p>Background. Application of various technological procedures for the manufacture of officinal preparation ointment against chilblains (Unguentum contra perniones) produce essential variations in the quality and stability of the final product. Changing the sequence of admixing active substances into the ointment base indicated the presence of incompatibility between the active substances, as well as between the active substances and the ointment base components. The aim was to examine the influence of various technological manufacturing procedures on quality and stability of the preparation. Methods. Changes in the samples of ointments and aqueous solutions of active substances were analyzed microscopically. Results. Microscopic analysis of hydrosoluble active substance solutions demonstrated destruction of ichthammol, induced by an acidic medium due to the dissolution of tannin and resorcinol, which is well known from the literature. It also demonstrated the destruction of tannin and resorcinol in aqueous solution, which had not been described in the literature. Application of the prescribed procedure for the manufacturing of ointment against chilblains, conceals the incompatibility reactions due to a slow dissolution of the tannin suspended in the officinal ointment base Unguentum cera lanae. Admixture of an ready-made aqueous solution of tannin caused an instant contact between ichthammol and the acidic medium, which caused the destruction or the complete absence of the formation of emulsion droplets. The problem of incompatibility reactions between lanolin alcohols in the ointment base and ichthammol and resorcinol, as well as the reaction between Peruvian balsam and sulfur from the ichthammol sulfate ion was observed. Numerous incompatibility reactions of ointment against chilblains, components indicated that it was necessary to introduce alterations in both the qualitative and quantitative composition of the preparation. Conclusion. Excipient preparation procedure, as well as the technological procedure for incorporation of active ingredients can cause the incompatibilities and therefore the formulation stability problems.<\/jats:p>","DOI":"10.2298\/vsp0504293b","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T11:29:27Z","timestamp":1291980567000},"page":"293-299","source":"Crossref","is-referenced-by-count":0,"title":["Influence of manufacturing procedure on stability of Unguentum contra perniones preparations"],"prefix":"10.2298","volume":"62","author":[{"given":"Mirjana","family":"Boskovic","sequence":"first","affiliation":[{"name":"Vojnomedicinska akademija, Institut za farmaciju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Toskic-Radojicic","sequence":"additional","affiliation":[{"name":"Vojnomedicinska akademija, Institut za farmaciju, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"ref1","author":"Pavlov V.","year":"1958","unstructured":"Pavlov V. (1958) Formulae magistrales et reagentia Beograd: Savez farmaceutskih dru\u0161tava Jugoslavije","journal-title":"Formulae magistrales et reagentia"},{"key":"ref10","author":"Bo\u0161kovic Mirjana","year":"2004","unstructured":"Bo\u0161kovic Mirjana (2004) The optimization of the formulation and technological process of ointment for chilblain Nurnberg: Kleinebudde P. Proceedings of the International Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology; March; Germany. Adritelf, APS, APV, EAPB, GSHI, HPS, PPS and VDI str. 421-2","journal-title":"The optimization of the formulation and technological process of ointment for chilblain"},{"key":"ref11","author":"Muravjov I.A.","year":"1980","unstructured":"Muravjov I.A. (1980) Drug technology Moscow: Medicine","journal-title":"Drug technology"},{"key":"ref12","author":"Senjkovic R.","year":"2003","unstructured":"Senjkovic R. 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(2004) Encyclopedia of drugs: Annual collection Moskva: RLS-2004","journal-title":"Encyclopedia of drugs: Annual collection"},{"key":"ref8","author":"***","year":"2000","unstructured":"*** (2000) Yugoslav pharmacopoeia Beograd: Savezni zavod za za\u0161titu zdravlja","journal-title":"Yugoslav pharmacopoeia"},{"key":"ref9","author":"***","year":"1995","unstructured":"*** (1995) The United State Pharmacopoeia Rookville: United States Pharmacopoeia Convention, Inc","journal-title":"The United State Pharmacopoeia"}],"container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:03:38Z","timestamp":1685358218000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84500504293B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp0504293b","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}