{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:55:44Z","timestamp":1722992144987},"reference-count":8,"publisher":"National Library of Serbia","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Introduction. Fast and precise diagnostics of the disease from the large\n   group of adult leukoencephalopathy is difficult but responsible job, because\n   the outcome of the disease is very often determined by its name. Cerebral\n   autosomal dominant arteriopathy with subcortical infarcts and\n   leukoencephalopathy (CADASIL) is caused by the mutation of Notch 3 gene on\n   chromosome locus 19p13. Beside the brain arterioles being the main disease\n   targets, extracerebral small blood vessels are affected by the pathological\n   process. Clinically present signs are recurrent ischemic strokes and vascular\n   dementia. CADASIL in its progressive form shows a distinctive pattern of\n   pathological changes on MRI of endocranium. The diagnosis is confirmed by the\n   presence of granular osmiophilic material (GOM) in histopathological skin\n   biopsies. Case reports. Two young adult patients manifested ischemic strokes\n   of unknown etiology, cognitive deterioration, migraine and psychopathological\n   phenomenology. MRI of endocranium pointed on CADASIL. Ultrastructural\n   examination of skin biopsy proved the presence of GOM in the basal lamina and\n   near smooth muscle cells of arteriole dermis leading to CADASIL diagnosis.\n   The presence of GOM in histopathological preparation is 100% specific for\n   CADASIL. The patients were not searched for mutation in Notch 3 gene on\n   chromosome 19, because some other leukoencephalopathy was disregarded.\n   Conclusion. Suggestive clinical picture, distinctive finding of endocranium\n   MRI, the presence of GOM by ultrastructural examination of histopathological\n   skin biopsies are sufficient to confirm CADASIL diagnosis.<\/jats:p>","DOI":"10.2298\/vsp1105455k","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T09:06:03Z","timestamp":1305623163000},"page":"455-459","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy"],"prefix":"10.2298","volume":"68","author":[{"given":"Zeljko","family":"Krsmanovic","sequence":"first","affiliation":[{"name":"Military Medical Academy, Neurology Clinic, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evica","family":"Dincic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Neurology Clinic, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smiljana","family":"Kostic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Neurology Clinic, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Lackovic","sequence":"additional","affiliation":[{"name":"School of medicine, Institute of Histology and Embryology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Bajcetic","sequence":"additional","affiliation":[{"name":"School of medicine, Institute of Histology and Embryology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Lackovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Institute of Psychiatry, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeljko","family":"Boskovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Neurology Clinic, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranko","family":"Raicevic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Neurology Clinic, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000245091.28429.6a"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000264018.46335.c8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00571504"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.4.577"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000048162.16852.88"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00636-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.048207"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4065\/76.12.1213"}],"container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:09:52Z","timestamp":1685358592000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501105455K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1105455k","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}