{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:55Z","timestamp":1747209475394,"version":"3.40.5"},"reference-count":30,"publisher":"National Library of Serbia","issue":"7","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Background\/Aim. Deregulation of the normal cell cycle is common in upper\n   urothelial carcinoma (UUC). The aim of this study was to investigate the\n   expression of regulatory proteins of the cell cycle (p53, p16, cyclin D1,\n   HER-2) and proliferative Ki-67 activity in UUC, and to determine their\n   interaction and influence on the phenotypic characteristics of UUC. Methods.\n   In 44 patients with UUC, histopathological and immunohistochemical analyses\n   (p53, p16, cyclin D1, HER-2, and Ki-67) of tumors were done. Results.\n   Overexpression\/ altered expression of p53, p16, cyclin D1 or HER-2 was\n   detected in 20%, 57%, 64%, and 57% of tumors, respectively. Eleven (25%) UUC\n   had a high proliferative Ki-67 index. Forty patients (91%) had at least one\n   marker altered, while four (9%) tumors had a wild-type status. Analysis of\n   relationship between expressions of molecular markers showed that only high\n   expression of p53 was significantly associated with altered p16 activity (p &lt;\n   0.05). High Ki-67 index was associated with the high stage (p &lt; 0.005), solid\n   growth (p &lt; 0.01), high grade (p &lt; 0.05), and multifocality p &lt; 0.05) of UUC,\n   while high expression of p53 was associated with the solid growth (p &lt; 0.05).\n   In regression models that included all molecular markers and phenotypic\n   characteristics, only Ki-67 correlated with the growth (p &lt; 0.0001), stage (p\n   &lt; 0.01), grade (p &lt; 0.05) and multifocality (p &lt; 0.05) of UUC; Ki-67 and\n   HER-2 expression correlated with the lymphovascular invasion (p &lt; 0.05).\n   Conclusions. This investigation showed that only negative regulatory proteins\n   of the cell cycle, p53 and p16, were significantly associated in UUC, while\n   proliferative marker Ki-67 was in relation to the key phenotypic\n   characteristics of UUC in the best way.<\/jats:p>","DOI":"10.2298\/vsp1107567d","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T08:03:48Z","timestamp":1310717028000},"page":"567-574","source":"Crossref","is-referenced-by-count":6,"title":["Expression of regulatory proteins and proliferative activity in relation to phenotypic characteristics of upper urothelial carcinoma"],"prefix":"10.2298","volume":"68","author":[{"given":"Zana","family":"Dolicanin","sequence":"first","affiliation":[{"name":"School of Medicine, Pri\u0161tina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-734X","authenticated-orcid":false,"given":"Ljubinka","family":"Jankovic-Velickovic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Visnjic","sequence":"additional","affiliation":[{"name":"School of Medicine, Clinic of Surgery, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Pesic","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Pathophysiology, 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