{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:57:56Z","timestamp":1747209476121,"version":"3.40.5"},"reference-count":13,"publisher":"National Library of Serbia","issue":"8","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Background\/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis\n   and asthma have had increased prevalence during the past decade and nowadays\n   occur in every third child in developed countries. The aim of the study was\n   to determine frequency and type of atopic diseases at the age of two, as well\n   as the importance the total IgE antibodies concentrations have in diagnosis\n   and prognosis of the disease. Methods. The study involved 175 children up to\n   two years of age. Allergy-like symptoms were found after surveying their\n   parents and pediatric medical records. Using the fluorescence immunossay\n   (FIA) method, total IgE antibodies concentrations and specific IgE antibodies\n   (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System.\n   Results. One or more allergy-like symptoms accounted for 57.7% of findings in\n   children under the age of two, whilst in 19.4% the existence of IgE-related\n   allergic diseases was found. Atopic diseases usually have clinical\n   manifestations of atopic dermatitis (11.4%), IgE-bound wheezing\/asthma\n   (10.8%) and food allergies (7.4%), and to much lesser extent those of\n   allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total\n   IgE antibodies concentrations were found in children with allergy-like\n   symptoms (p &lt; 0.0005) (cut-off 15.15 kU\/L, sensitivity 76.5% specificity\n   71.6%). Conclusion. Almost 20% of two-year-old children have any of\n   clinically manifested allergic diseases, with atopic dermatitis and IgE\n   wheeze\/asthma being predominant. The higher total IgE antibodies\n   concentration is a good marker for sensitization in children with\n   allergy-like symptoms.<\/jats:p>","DOI":"10.2298\/vsp1108690i","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T12:17:58Z","timestamp":1314101878000},"page":"690-695","source":"Crossref","is-referenced-by-count":1,"title":["Clinical manifestations of atopy in children up to two years of age"],"prefix":"10.2298","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-942X","authenticated-orcid":false,"given":"Nevenka","family":"Ilic","sequence":"first","affiliation":[{"name":"Institut za javno zdravlje, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Velickovic","sequence":"additional","affiliation":[{"name":"De\u010diji dispanzer, Savetovali\u0161te za alergije, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragoljub","family":"Djokic","sequence":"additional","affiliation":[{"name":"Institut za javno zdravlje, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebojsa","family":"Rankovic","sequence":"additional","affiliation":[{"name":"Institut za javno zdravlje, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-3178","authenticated-orcid":false,"given":"Gordana","family":"Kostic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Kragujevac, Klinika za pedijatriju, Kardiolo\u0161ko-pulmolo\u0161ko odeljenje, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-5144","authenticated-orcid":false,"given":"Marina","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Klini\u010dki centar Kragujevac, Interna klinika, Centar za pulmologiju, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Radunovic","sequence":"additional","affiliation":[{"name":"Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Baskic","sequence":"additional","affiliation":[{"name":"Institut za javno zdravlje, Kragujevac + Medicinski fakultet, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-001-0071-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.1.20"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62603-8"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60526-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00238.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62714-7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61390-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00649.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.020"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70164-2"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2298\/SARH0910558Z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e33"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0627"}],"container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:10:06Z","timestamp":1685358606000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501108690I"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1108690i","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"type":"print","value":"0042-8450"},{"type":"electronic","value":"2406-0720"}],"subject":[],"published":{"date-parts":[[2011]]}}}