{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:08:23Z","timestamp":1771052903716,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175076"],"award-info":[{"award-number":["175076"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Background\/Aim. Zinc is an essential element which has considerable\n   interaction with gamma-aminobutyric acid A type receptors (GABAA) and\n   glutamate receptors in the central nervous system (CNS). It is believed that\n   zinc acts as a potent inhibitor of glutamate N-methyl-D-aspartate (NMDA)\n   receptors, and binding to structurally specific site on the GABAA receptor\n   leads to inhibition of GABA dependent Cl-pass. The aim of our research was to\n   test the anxiolytic and antidepressant effects of zinc after single\n   application and its influence on general behavioural parameters after\n   repeated administration. Methods. Male Wistar rats were treated with\n   increasing doses of zinc histidine dehydrate (10, 20, 30 mg\/kg, i.p.). To\n   determine anxiolytic and antidepressant properties of zinc two models were\n   used: elevated plus maze (EPM) and forced swim test (FST). Behavioural\n   parameters (stillness and mobility) were, also, recorded after single and\n   repeated administration of active substance. Results. Testing animals in the\n   EPM showed a statistically significant difference as follows: dose of 20\n   mg\/kg significantly increased the time animals spent in open arms, indicating\n   an acute anxiolytic effect, while doses of 30 mg\/kg significantly reduced the\n   time in the open arms, indicating a potentially anxiogenic effect. Testing\n   the animals by FST showed a statistically significant difference in\n   immobility time of animals treated with the lowest applied (10 mg\/kg) and\n   highest applied (30 mg\/kg) doses of zinc, compared to the control group. The\n   first day of testing behavioral parameters showed the tendency to increase\n   locomotor activity of the animals with the lowest dose of zinc (10 mg\/kg),\n   while the following day revealed a reduced activity with the highest dose\n   applied (30 mg\/kg). Conclusion. Zinc has important effects on the CNS: After\n   single application, in all doses zinc showed antidepressant effects. The\n   effects of zinc on anxiety and locomotor activity showed dose-dependent\n   bidirectional effects.<\/jats:p>","DOI":"10.2298\/vsp111129036s","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T14:13:46Z","timestamp":1351606426000},"page":"391-395","source":"Crossref","is-referenced-by-count":12,"title":["Anxiolytic and antidepressant effect of zinc on rats and its impact on general behavioural parameters"],"prefix":"10.2298","volume":"70","author":[{"given":"Janko","family":"Samardzic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Savic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nemanja","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radomir","family":"Matunovic","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Baltezarevic","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miljana","family":"Obradovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Histology and Embriology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasna","family":"Jancic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic of Neurology and Psychiatry for Children and Adolescents, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Opric","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Obradovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:10:41Z","timestamp":1685358641000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501200036S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp111129036s","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}