{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:58:02Z","timestamp":1747209482500,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Conjunctival metastasis is exceedingly rare, and it is, as a\n   rule, a sign of advanced malignant disease with poor prognosis. We presented\n   a female patient with breast cancer metastasis to the conjunctiva. Case\n   report. A 45-yearold premenopausal female patient was presented with a\n   solitary, yellowish, thin, demarcated lesion in the superior nasal quadrant\n   of the bulbar conjunctiva of the left eye noted by chance a week earlier.\n   There was no sign of irritation, and no pain, and no other functional or\n   morphological problem in either eye or orbit. Five years before the\n   appearance of conjunctival metastasis, breast carcinoma was diagnosed and the\n   patient underwent chemotherapy, preoperative radiotherapy and radical\n   mastectomy. Three years later, computed tomography scan showed metastasis in\n   the left hepatic lobe with ascites and the patient underwent chemotherapy\n   again. But, four months prior to the appearance of conjunctival lesion body\n   scintigraphy showed multifocal sceletal lesions and nuclear magnetic\n   resonance revealed diffuse hepatic metastases and bilateral ovarial tumors.\n   Paliative radiotherapy and hormonal therapy (megestrol, 160 mg) were carried\n   out. An excisional biopsy of the observed conjunctival lesion was performed\n   under topical anesthesia and the material was subjected to histopathological\n   (HP) examination. HP and immunohistochemical examinations established the\n   presence of breast infiltrating lobular carcinoma metastatic to the\n   conjunctiva. The patient showed rapid deterioration after intervention, and\n   died after three weeks. Conclusion. A survival period less than one month\n   after the appearance of conjunctival metastasis deserves attention because it\n   is unexpected and has never been reported previously. It is not a rule that\n   HP presentation of a metastatic lesion is so characteristic that it is\n   possible to determine a primary tumor.<\/jats:p>","DOI":"10.2298\/vsp120322040b","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T07:40:13Z","timestamp":1353483613000},"page":"331-334","source":"Crossref","is-referenced-by-count":4,"title":["Breast cancer metastasis to the conjunctiva"],"prefix":"10.2298","volume":"70","author":[{"given":"Anica","family":"Bobic-Radovanovic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Belgrade + Clinic of Eye Disease, Clinical Center of Serbia, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Rasic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Clinic of Eye Disease, Clinical Center of Serbia, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Buta","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3041-7339","authenticated-orcid":false,"given":"Radan","family":"Dzodic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade + Institute of Oncology and Radiology of Serbia, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:10:43Z","timestamp":1685358643000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501200040B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp120322040b","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"type":"print","value":"0042-8450"},{"type":"electronic","value":"2406-0720"}],"subject":[],"published":{"date-parts":[[2013]]}}}