{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:07:43Z","timestamp":1685419663876},"reference-count":0,"publisher":"National Library of Serbia","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Background\/Aim. There are a lot of studies aiding to the opinion that the\n   involvement degree of axilla lymph nodes grows depending on increase of\n   breast tumor size, and its histological and nuclear grades. The aim of this\n   study was to assess the risk of axillary lymph nodes involvement, as well as\n   the relation between the tumor size, histological and nuclear grades in a\n   group of female patients who underwent breast cancer surgery, including\n   levels 1-3 axillary dissection. Methods. Investigation covered 900 patients\n   operated on during 2005-2008 who underwent modified radical mastectomy\n   including axillar dissection. We assessed a number of involved lymph nodes,\n   depending on tumor macroscopic size (T), histological grade (HG) and nuclear\n   grade (NG). Results. A total number of examined lymph nodes was 9977. The\n   incidence of involved lymph nodes was from 18.6% with T1 tumor size up to\n   60.2% with T4 tumor size. Concerning histological grade, the number of\n   involved lymph nodes ranged from 14.2% (HGI) to 45.1% (HGIII); while in terms\n   of nuclear grade, the number of involved lymph nodes ranged from 17.4% (NGI)\n   to 54.5% (NGIV). By using ?2-test for trend and odds ratio (OR), the results\n   showed that the axillary lymph nodes involvement degree was increased with\n   the increase of the tumor size and its histological and nuclear grades. The\n   risk of axillary lymphatic nodes involvement was 1.43 times higher in the\n   group of T2 tumors size compared to the smaller tumors T1 size, and even up\n   to 6.62 times higher in case of T4 tumor size. It was also increasied from\n   1.79 times for HGII to even 4.98 times for HGIII, and from 1.44 times for\n   NGII to 5.71 times for NGIV. Conclusion. In breast cancer patients, there is\n   a strong correlation between tumor size, its histological and nuclear grades\n   and the risk of axillary lymph nodes involvement.<\/jats:p>","DOI":"10.2298\/vsp1205414b","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T07:26:58Z","timestamp":1337066818000},"page":"414-419","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades"],"prefix":"10.2298","volume":"69","author":[{"given":"Toplica","family":"Bojic","sequence":"first","affiliation":[{"name":"Hirur\u0161ka klinika Klini\u010dkog centra Ni\u0161, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebojsa","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"Hirur\u0161ka klinika Klini\u010dkog centra Ni\u0161, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Karanikolic","sequence":"additional","affiliation":[{"name":"Hirur\u0161ka klinika Klini\u010dkog centra Ni\u0161, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sladjana","family":"Filipovic","sequence":"additional","affiliation":[{"name":"Klinika za onkologiju Klini\u010dkog centra Ni\u0161, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Granic","sequence":"additional","affiliation":[{"name":"KBC Be\u017eanijska kosa, Beograd"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"A.","given":"Antigoni","family":"Poultsidi","sequence":"additional","affiliation":[{"name":"University Hospital, Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:11:08Z","timestamp":1685358668000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501205414B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1205414b","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}