{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T20:23:43Z","timestamp":1749414223510,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"8","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175024 i\n   ?European AIDS Treatment Network? (NEAT)"],"award-info":[{"award-number":["175024 i\n   ?European AIDS Treatment Network? (NEAT)"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background\/Aim. Highly active antiretroviral therapy (HAART) has led to\n   dramatic reductions in mortality and morbidity of HIV\/AIDS-patients.\n   Lipodystrophy, a syndrome including peripheral fat wasting and central\n   obesity, is well-documented side effect of HAART. The aim of this study was\n   to evaluate the incidence of lipodystrophy, and to determine its risk ratios\n   in a HIV\/AIDS cohort. Methods. This cross-sectional study included all\n   antiretroviral-naive HIV\/AIDS patients commencing HAART from October 1, 2001\n   to October 1, 2010, in the HIV\/AIDS Center, Institute of Infectious and\n   Tropical Diseases, Belgrade, Serbia. Univariate and stepwise multivariate\n   logistic regression analyses were used to determine the odds ratios (OR) with\n   the confidence interval (CI) of 95%, in order to establish the relative risk\n   for lipodystrophy. The Kaplan-Meier-method was used to determine the\n   probability of development lipodystrophy over time. All statistical analyses\n   were performed using SPSS software version using 0.05 as a p-treshold for the\n   significance. Results. This study included 840 HIV\/AIDS patients, 608 women\n   and 232 men, followed for 5.6 ? 2.8 years. The prevalence of lipodystrophy\n   was 69.2%. Univariate and stepwise multivariate regression analysis\n   identified that the female gender, hepatitis C coinfection, AIDS diagnosis\n   prior to HAART initiation, nucleoside-reverse-transcriptase-inhibitors and\n   proteaseinhibitors based regimens had a high risk for developing\n   lipodystrophy in HIV\/AIDS-patients (OR = 1.6, 95% CI = 1.1-3.49, p = 0.04; OR\n   = 3.31, 95% CI = 1.4 - 3.8, p &lt; 0.01; OR = 3.7, 95% CI = 1.7 - 6.1, p &lt; 0.01;\n   OR = 2.1, 95% CI = 1.7 - 3.3, p &lt; 0.01; OR = 6.1, 95% CI = 4.1 - 9.7, p &lt;\n   0.01, respectively). Conclusion. Despite much greater life expectancy of\n   HIV\/AIDSpatients, treatment-related toxicities still remain a major concern.\n   Monitoring of lipodystrophy, as side effect of HAART, is particularly\n   important.<\/jats:p>","DOI":"10.2298\/vsp121016022d","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T12:52:31Z","timestamp":1396356751000},"page":"746-750","source":"Crossref","is-referenced-by-count":7,"title":["Lipodystrophy induced by combination antiretroviral therapy in HIV\/AIDS patients: A Belgrade cohort study"],"prefix":"10.2298","volume":"71","author":[{"given":"Gordana","family":"Dragovic","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Danilovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Dimic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djordje","family":"Jevtovic","sequence":"additional","affiliation":[{"name":"Institute of Infective and Tropical Diseases \u201cDr Kosta Todorovic\u201d, Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:13:23Z","timestamp":1685358803000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501400022D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp121016022d","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"type":"print","value":"0042-8450"},{"type":"electronic","value":"2406-0720"}],"subject":[],"published":{"date-parts":[[2014]]}}}