{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T17:05:20Z","timestamp":1748365520852,"version":"3.40.5"},"reference-count":0,"publisher":"National Library of Serbia","issue":"10","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"Background\/Aim. Benign acini in benign prostatic hyperplasia (BPH) are lined\n with pseudostratified cylindrical epithelium with a continuous basal cell\n layer. Adenocarcinoma of the prostate is the most common cancer in men. High\n gradus-prostatic intraepithelial neoplasia (HGPIN) lesions precede invasive\n cancer. Prostate adenocarcinoma (PCa) implies a complete absence of basal\n cells and stromal invasion by malignant acini. Estrogen receptor (ER) is\n located in nuclei of acinar basal and secretory cells and partially in\n stromal cells. The aim of this research was to demonstrate and localize ER\n in BPH and in PCa of different Gleason scores. Considering literature data\n for ER-beta expression in different morphologic prostate lesions, it is\n assumed that there is expression of ER-beta in most moderately\n differentiated PCa, and that the observed receptor expression is lost with\n increasing of the Gleason score. Methods. Four groups of patients were\n formed: the control with BPH and three experimental groups with PCa of\n different grades and scores, according to the Gleason grading system. The\n patients were male of various ages suspected of PCa, based on clinical and\n laboratory parameters. The study was conducted in a period 2010-2012. None\n of the patients received prior hormonal therapy. Sextant byopsies with BPH\n and PCa were treated for ER-beta (Novocastra). Localization and intensity of\n ER-beta expression is reported through the score: 0 = zero; 1 = < 1%; 2 =\n 1-10%; 3 = 11-33%; 4 = 34-66%; 5 - > 66%. Positive fibroblasts and\n endothelial cells are used for comparison. Results. ER-beta expression in\n acinar epithelial cells was the weakest in welldifferentiated\n adenocarcinoma. A decline of ER-beta expression was noticed in malignant\n lesions of the prostate vs benign ones. Less differentiated adenocarcinomas\n showed a decrease of ER-beta expression in basal and in the secretory cells.\n ERbeta expression in basal cells was stronger than in secretory ones in BPH\n and well-differentiated adenocarcinoma. Conclusion. ER-beta expression was\n most pronounced in BHP samples and declined in malignant prostatic lesions.\n This finding supports statement on antiproliferative role of ERbeta in\n prostatic tissue.<\/jats:p>","DOI":"10.2298\/vsp131022069f","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T13:47:14Z","timestamp":1441028834000},"page":"906-913","source":"Crossref","is-referenced-by-count":7,"title":["The expression and localization of estrogen receptor beta in hyperplastic and neoplastic prostate lesions"],"prefix":"10.2298","volume":"72","author":[{"given":"Aleksandra","family":"Fejsa-Levakov","sequence":"first","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Histology and Embryology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Mocko-Kacanski","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Histology and Embryology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-4806","authenticated-orcid":false,"given":"Nada","family":"Vuckovic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Pathology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Zivojinov","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Pathology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Amidzic","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Histology and Embryology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Ilic-Sabo","sequence":"additional","affiliation":[{"name":"Clinical Center of Vojvodina, Pathology and Histology Center, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department for Histology and Embryology, Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:15:23Z","timestamp":1685358923000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501500069F"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp131022069f","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"type":"print","value":"0042-8450"},{"type":"electronic","value":"2406-0720"}],"subject":[],"published":{"date-parts":[[2015]]}}}