{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:40:57Z","timestamp":1788871257331,"version":"build-2803163510"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["145070"],"award-info":[{"award-number":["145070"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2013]]},"abstract":"Background\/Aim. The number of patients with end-stage renal diseases treated\n with chronic dialysis is increasing over the last years. Long-term peritoneal\n dialysis is associated with progressive development of structural and\n functional alterations of peritoneal membrane. The aim of the study was to\n analyze ultrastructural alterations of mesothelial monolayer and\n submesothelial tissue in a modified nonuremic experimental model of\n peritoneal dialysis in rabbits. Methods. The study was performed on 5 healthy\n Chinchilla rabbits. Surgical procedures of implantation and removal of\n peritoneal catheter, prevention of catheter clothing, prevention of infection\n and dialysate instillation were performed according to previously described\n protocols. Peritoneal tissue samples were collected upon catheter placement\n and removal after a 5-week follow-up and processed for transmission electron\n microscopy (TEM) examination. Results. The rabbits tolerated anesthesia,\n surgical procedure and the applied regimen of dialysate instillations well.\n The animals recovered completely and no adverse effects were noted. In the\n animals treated with peritoneal dialysis instillations, TEM revealed\n alterations of the mesothelial monolayer and submesothelial tissue. The\n mesothelial cells in direct contact with dialysis fluid were prone to\n shrinking. They lost the typical cobblestone morphology and assumed a\n flattened shape. The mesothelial cells were often detached from the basement\n membrane. These cells showed euchromatic nuclei, higher number of microvilli\n in their apical part and very numerous vesicles. A higher quantity of\n collagen fibers was noticed in the peritoneal lamina propria in close\n relation to the basement membrane of mesothelium. The nuclei of the\n fibroblasts were also euchromatic. Numerous mitochondria, granules and\n vesicles were present in their cytoplasm. Conclusion. The used rabbit model\n of peritoneal dialysis is simple, practical to perform, reproducible, not\n expensive and not requiring advanced devices. It is suitable for obtaining\n peritoneal tissue samples for histological examination and can be used to\n analyze the effects of dialysis solutions on the rabbit peritoneal membrane.<\/jats:p>","DOI":"10.2298\/vsp1311023j","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T03:37:14Z","timestamp":1383709034000},"page":"1023-1028","source":"Crossref","is-referenced-by-count":2,"title":["Ultrastructural changes of the peritoneum in a rabbit model of peritoneal dialysis"],"prefix":"10.2298","volume":"70","author":[{"given":"Natasa","family":"Jovanovic","sequence":"first","affiliation":[{"name":"Clinical Center of Serbia, Clinic of Nephrology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezana","family":"Zunic-Bozinovski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathophysiology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusan","family":"Trpinac","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Histology and Embriology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeljko","family":"Lausevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Digestive Diseases, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Krstic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Digestive Diseases, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Opric","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Trbojevic-Stankovic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center \u201eDr Dragi\u0161a Mi\u0161ovi\u0107\u201c, Department of Hemodialysis and Nephrology, Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Stojimirovic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Clinical Center of Serbia, and Faculty of Medicine, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T07:13:05Z","timestamp":1685344385000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501311023J"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1311023j","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}