{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:10:00Z","timestamp":1685419800632},"reference-count":0,"publisher":"National Library of Serbia","issue":"12","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Introduction. Langerhans cell histiocytosis (LCH) is an uncommon disease of\n   unknown etiology characterized by uncontrolled proliferation and infiltration\n   of various organs by Langerhans cells. Case report. We presented a\n   54-year-old man, heavy smoker, with dyspnea, cough, hemoptysis, headache and\n   ataxia, who died shortly after admission to our hospital. On the autopsy,\n   tumor was found in the posterior segment of the right upper pulmonary lobe as\n   well as a right-sided occipitoparietal lesion which penetrated into the right\n   ventricle resulting in internal and external hematocephalus. Histologically\n   and immunohistohemically, the diagnosis of primary lung adenocarcinoma with\n   brain metastasis was made (tumor cells showed positivity for CK7 and TTF-1\n   which confirmed the diagnosis). In the lung parenchyma around the tumor, as\n   well as in brain tissue around the metastatic adenocarcinoma histiocytic\n   lesions were found. Light microscopic examination of the other organs also\n   showed histiocytic lesions involving the pituitary gland, hypothalamus,\n   spleen and mediastinal lymph nodes. Immunohistochemical studies revealed\n   CD68, S-100 and CD1a immunoreactivity within the histiocytes upon which the\n   diagnosis of Langerhans' cells histiocytosis was made. Conclusion. The\n   multisystem form of LCH with extensive organ involvement was an incidental\n   finding, while metastatic lung adenocarcinoma to the brain that led to\n   hematocephalus was the cause of death.<\/jats:p>","DOI":"10.2298\/vsp1312159l","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T10:26:45Z","timestamp":1386584805000},"page":"1159-1161","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem Langerhans cell histiocytosis coexisting with metastasizing adenocarcinoma of the lung: A case report"],"prefix":"10.2298","volume":"70","author":[{"given":"Aleksandra","family":"Lovrenski","sequence":"first","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirna","family":"Djuric","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Novi Sad + Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pulmology, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istvan","family":"Klem","sequence":"additional","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zivka","family":"Eri","sequence":"additional","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milana","family":"Panjkovic","sequence":"additional","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Tegeltija","sequence":"additional","affiliation":[{"name":"Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica + Faculty of Medicine, Novi Sad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djordje","family":"Povazan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Novi Sad + Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pulmology, Sremska Kamenica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:13:13Z","timestamp":1685358793000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501312159L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1312159l","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}