{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:11:42Z","timestamp":1771546302084,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"Background\/Aim. Intramyocardial bone marrow mononuclear cells (BMMNC)\n implantation concomitant to coronary artery bypass grafting (CABG) surgery\n as an option for regenerative therapy in chronic ischemic heart failure was\n tested in a very few number of studies, with not consistent conclusions\n regarding improvement in left ventricular function, and with a follow-up\n period between 6 months and 1 year. This study was focused on testing of the\n hypothesis that intramyocardial BMMNC implantation, concomitant to CABG\n surgery in ischemic cardiomyopathy patients, leads to better postoperative\n long-term results regarding the primary endpoint of conditional\n status-functional capacity and the secondary endpoint of mortality than CABG\n surgery alone in a median follow-up period of 5 years. Methods. A total of\n 30 patients with ischemic cardiomyopathy and the median left ventricular\n ejection fraction (LVEF) of 35.9 ? 4.7% were prospectively and randomly\n enrolled in a single center interventional, open labeled clinical trial as\n two groups: group I of 15 patients designated as the study group to receive\n CABG surgery and intramyocardial implantation of BMMNC and group II of 15\n patients as the control group to receive only the CABG procedure. All the\n patients in both groups received the average of 3.4 ? 0.7 implanted coronary\n grafts, and all of them received the left internal mammary artery (LIMA) to\n the left anterior descending (LAD) and autovenous to other coronaries.\n Results. The group with BMMNC and CABG had the average of 17.5 ? 3.8\n injections of BMMNC suspension with the average number of injected bone\n marrow mononuclear cells of 70.7 ? 32.4 ? 106 in the total average volume of\n 5.7 ? 1.5 mL. In this volume the average count of CD34+ and CD133+ cells was\n 3.96 ? 2.77 ? 106 and 2.65 ? 1.71 ? 106, respectively. All the patients were\n followed up in 2.5 to 7.5 years (median, 5 years). At the end of the\n follow-up period, significantly more patients from the group that received\n BMMNC were in the functional class I compared to the CABG only group (14\/15\n vs 5\/15; p = 0.002). After 6 months the results on 6-minute walk test\n (6-MWT) were significantly different between the groups (435 m in the BMMNC\n and CABG group and 315 m in the CABG only group; p = 0.001), and continued\n to be preserved and improved on the final follow-up (520 m in the BMMNC and\n CABG group vs 343 m in the CABG only group; p < 0.001). Cardiovascular\n mortality was also significantly reduced in the BMMNC and CABG group (p =\n 0.049). Conclusion. Implanatation of BMMNC concomitant to CABG is a safe and\n feasible procedure that demonstates not only the improved functional\n capacity but also a reduced cardiac mortality in a 5-year follow-up in\n patients with ischemic cardiomyopathy scheduled for CABG surgery.<\/jats:p>","DOI":"10.2298\/vsp140109071t","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T16:50:25Z","timestamp":1417452625000},"page":"225-232","source":"Crossref","is-referenced-by-count":15,"title":["Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation: A long term follow-up study"],"prefix":"10.2298","volume":"72","author":[{"given":"Zoran","family":"Trifunovic","sequence":"first","affiliation":[{"name":"Military Medical Academy, Cardiac Surgery Clinic, Belgrade + University of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Obradovic","sequence":"additional","affiliation":[{"name":"University of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Clinic for Emergency and Internal Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Balint","sequence":"additional","affiliation":[{"name":"University of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute for Transfusiology and Hemobiology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoje","family":"Ilic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Cardiac Surgery Clinic, Belgrade + University of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Vukic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Anestesiology and Intensive Care, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Sisic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Nuclear Medicine Institute, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-4335","authenticated-orcid":false,"given":"Jelena","family":"Kostic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Center of Serbia, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinisa","family":"Rusovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Radiology Institute, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Dobric","sequence":"additional","affiliation":[{"name":"Clinical Center of Serbia, Department of Cardiology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Ostojic","sequence":"additional","affiliation":[{"name":"University of Defense, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute for Transfusiology and Hemobiology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:13:46Z","timestamp":1685358826000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501400071T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140109071t","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}