{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T09:52:22Z","timestamp":1713261142316},"reference-count":0,"publisher":"National Library of Serbia","issue":"2","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. Immunoglobulin D (IgD) myeloma is a rare disease, about 2% of\n   all myelomas, even rarer when accompanied with another multiple myeloma in\n   biclonal gammopathy. We presented a case of biclonal gammopathy - associated\n   manifestation of IgD myeloma and light chain disease in a patient who\n   initially had renal failure. Case report. 37-year-old male approximately one\n   month before hospitalization began to feel malaise and fatigue along with\n   decreased urination. Laboratory analysis revealed azotemia. A dialysis\n   catheter was placed and hemodialysis started. The patient was then admitted\n   to our hospital for further tests and during admission, objective examination\n   revealed pronounced paleness with hepatosplenomegaly and hypertension (170\/95\n   mmHg). Laboratory analysis showed erythrocyte sedimentation rate 122 mm\/h,\n   expressed anemic syndrome (Hb 71 g\/L) and renal failure dialysis rank:\n   creatinine 1,408 ?mol\/L, urea31.7 mmol\/L. There was two M components in serum\n   protein electrophoresis: IgD lambda and free light chain lambda. Proteinuria\n   was nephrotic rank (5.4 g\/24 h), whose electrophoresis revealed 2 M\n   components - massive in ? 2 fraction of 71%; 7% in the discrete ? fraction,\n   beta 2M \/serum 110 mg\/L, in urine 1.8 mg\/L - extremely high; IgL kappa \/\n   lambda index 1 : 13 (reference value ratio 2 : 1). The findings pointed to\n   double myeloma disease: IgD myeloma and Bence Jones lambda myeloma. Bone\n   biopsy confirmed IgD myeloma lambda 100% infiltration medulla predominantly\n   plasmablasts. The treatment continued with hemodialysis 3 times per week with\n   chemotherapy protocol bortezomib, doxorubicin, dexamethasone. After 4 cycles\n   of chemotherapy, there was a decrease of IgD, ? - light chains, reduction in\n   proteinuria (1.03 g\/24 h), so hemodialysis was reduced to once per week. Six\n   months after treatment initiation the patient underwent autologous bone\n   marrow transplantation. In a 2-year follow-up period double myeloma disease\n   showed complete remission. Conclusion. The presented rare form of double\n   myeloma disease with initial renal insufficiency underscores the importance\n   of careful observation and team-work that can alter the course of this\n   serious disease.<\/jats:p>","DOI":"10.2298\/vsp140210027r","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T10:11:48Z","timestamp":1398852708000},"page":"196-199","source":"Crossref","is-referenced-by-count":5,"title":["Kidney failure as an unusual initial presentation of biclonal gammopathy (IgD multiple myeloma associated with light chain disease): A case report"],"prefix":"10.2298","volume":"72","author":[{"given":"Violeta","family":"Rabrenovic","sequence":"first","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade + Medical Faculty of the Military Medical Academy, University of Defense, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Mijuskovic","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defense, Belgrade + Institute of Medical Biochemistry, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan","family":"Marjanovic","sequence":"additional","affiliation":[{"name":"Medical Faculty of the Military Medical Academy, University of Defense, Belgrade + Clinic of Hematology, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milorad","family":"Rabrenovic","sequence":"additional","affiliation":[{"name":"Center of Hyperbaric Medicine, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade + Medical Faculty of the Military Medical Academy, University of Defense, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Antic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Ignjatovic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Petrovic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Pilcevic","sequence":"additional","affiliation":[{"name":"Clinic of Nephrology, Military Medical Academy, Belgrade + Medical Faculty of the Military Medical Academy, University of Defense, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:13:26Z","timestamp":1685358806000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501400027R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140210027r","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}