{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:30:09Z","timestamp":1773297009686,"version":"3.50.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"2","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Background\/Aim. In recent years, the focus of interest of the scientific\n   community is the application of heart markers as early indicators and\n   prognostic parameters of perinatal asphyxia (PA). The aim of this study was\n   to evaluate the significance of clinical application of heart markers in term\n   newborns with perinatal asphyxia. Methods. During a 3- year period we\n   analyzed 91 full-term newborns (55 with and 36 without perinatal asphyxia).\n   In all the subjects within the first 24-48 h after birth, we simultaneously\n   determined serum concentrations of cardiac troponin I, brain natriuretic\n   peptide, MB fraction of creatine kinase (CK-MB) and Creactive protein.\n   Results. In the group of full-term neonates with PA significantly higher\n   levels of cardiac troponinI (p = 0.000), CK-MB fraction (p = 0.000), brain\n   natriuretic peptide (p = 0.003) and C-reactive protein (p = 0.017) were\n   found, compared to the group of healthy full-term newborns. In merged group\n   (n = 91) cardiac troponin I level correlated with the fifth minute Apgar\n   score (r = - 0.637, p = 0.000) and the serum lactate concentration in the\n   first 12h after birth (r = 0.529, p = 0.000). Early increase in cardiac\n   troponin I &gt; 0.135 ?g\/L predicted the risk of death with the sensitivity of\n   84.6% and specificity of 85.9%, while the increase in CK-MB fraction, brain\n   natriuretic peptide and C-reactive protein did not have a predictive value\n   with respect to a mortality outcome. Conclusion. Among the tested cardiac\n   markers, cardiac troponin I is the most sensitive and the only reliable early\n   predictor of mortality in fullterm neonates with perinatal asphyxia.<\/jats:p>","DOI":"10.2298\/vsp1402149s","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T10:18:30Z","timestamp":1392113910000},"page":"149-155","source":"Crossref","is-referenced-by-count":6,"title":["The role of biochemical markers as early indicators of cardiac damage and prognostic parameters of perinatal asphyxia"],"prefix":"10.2298","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-1972","authenticated-orcid":false,"suffix":"M.","given":"Aleksandra","family":"Simovic","sequence":"first","affiliation":[{"name":"Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medicine, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Lj.","given":"Jovan","family":"Kosutic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Care Institute \u201cDr Vukan \u0107upi\u0107\u201d, Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"M.","given":"Sergej","family":"Prijic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Care Institute \u201cDr Vukan \u0107upi\u0107\u201d, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-6687","authenticated-orcid":false,"suffix":"B.","given":"Jasmina","family":"Knezevic","sequence":"additional","affiliation":[{"name":"Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medicine, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-6898","authenticated-orcid":false,"suffix":"J.","given":"Ana","family":"Vujic","sequence":"additional","affiliation":[{"name":"Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medicine, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"D.","given":"Nadezda","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:13:58Z","timestamp":1685358838000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501402149S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp1402149s","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}