{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:51:02Z","timestamp":1769518262788,"version":"3.49.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Background\/Aim. Although chlorpromazine (CPZ) is an antipsychotic drug widely\n   used in clinical practice for a long time, its mechanism of action has not\n   been entirely defined. An extremely difficult managing of patients acutely\n   poisoned with CPZ is additional reason for detailed studying its toxicity\n   mechanisms. In this clinical study, we investigated whether the oxidative\n   stress (OS) mediates CPZ toxic effects in the exposed patients. Methods. The\n   patients were organized into 3 groups: the T-group - hospitalized patients\n   receiving therapeutic doses of 75-150 mg CPZ\/day; the overdosed group,\n   divided into two subgroups: the group M and the group S - mildly (CPZ serum\n   concentration: 0.21 ? 0.05 mg\/L) and severely (CPZ serum concentration: 2.66\n   ? 0.25 mg\/L) poisoned patients, respectively, and the group C (control group\n   of healthy volunteers). Oxidative stress parameters [total antioxidative\n   status (TAS) and malondialdehyde (MDA) in plasma)] and superoxide dismutase\n   (SOD) activity in erythrocytes were measured spectrophotometrically, and CPZ\n   concentrations in serum were monitored chromatographically. One set of\n   measurements was performed in the group C and T, whereas two sets of\n   measurements (after 24 hours and 48 hours) were done in the poisoned\n   patients, groups M and S. Results. A decrease of TAS and increase of SOD\n   activity were obtained in both subgroups of the poisoned patients, compared\n   to the controls and the group receiving therapeutic doses of CPZ. A\n   significant increase of MDA was achieved in severely poisoned patients,\n   compared to all other groups. Conclusion. Changed oxidative stress\n   parameters in patients poisoned with chlorpromazine indicate involvement of\n   oxidative stress in the toxicity mechanism(s) of chlorpromazine.<\/jats:p>","DOI":"10.2298\/vsp140423047d","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T12:41:14Z","timestamp":1434631274000},"page":"312-317","source":"Crossref","is-referenced-by-count":7,"title":["Oxidative stress induced by chlorpromazine in patients treated and acutely poisoned with the drug"],"prefix":"10.2298","volume":"73","author":[{"given":"Bratislav","family":"Dejanovic","sequence":"first","affiliation":[{"name":"Military Medical Center \u201cKaraburma\u201d, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Vukovic-Dejanovic","sequence":"additional","affiliation":[{"name":"Institute for Rehabilitation, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Institute for Medical Research, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-9370","authenticated-orcid":false,"given":"Ivana","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"University of Ni\u0161, Faculty of Medicine, Institute for Biochemistry, Ni\u0161, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Mandic-Gajic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic of Psychiatry, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanda","family":"Dilber","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:15:14Z","timestamp":1685358914000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501500047D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140423047d","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}