{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:30:35Z","timestamp":1790742635110,"version":"4.1.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"12","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Background\/Aim. Immune system disorder, including inflammation, takes a\n   significant place when considering still unclear etiology of schizophrenia.\n   The aim of this study was to determine the blood levels of nonspecific\n   inflammation markers in the first episode of schizophrenia and their relation\n   to the therapy response. Methods. In this study we determined the blood\n   levels of nonspecific inflammation markers: white blood cells count (WBC),\n   C-reactive protein (CRP), erythrocytes sedimentation rate (ESR) and the\n   elements of differential white blood cell counts (or the leukocyte formula):\n   granulocytes (Gra), lymphocytes (Lym) and monocytes (Mon), in the first\n   episode of schizofrenia, in 78 patients hospitalized at the Clinic for\n   Psychiatric Disorders ?Dr Laza Lazarevic? in Belgrade. The levels were\n   measured at admission to the clinic, as well as after 4 weeks of\n   antipsychotic treatment. The Positive and negative syndrome scale for\n   schizophrenia (PANSS) was applied to measure the severity of psychopathology\n   and response to the treatment. Results. During the first episode of\n   schizophrenia, before initiation of antipsychotic treatment, the frequency of\n   abnormal values was high (? 25% of the patients) for the following\n   non-specific inflammation markers: WBC, CRP, ESR and Gra, in the leukocyte\n   formula, but dropped after 4 weeks of antipsychotic treatment at the level of\n   high statistical significance for WBC and Gra (p &lt; 0.001). The ESR remained\n   unchanged in as many as 50% of the patients even after 4-week antipsychotic\n   treatment, at the level of statistical significance in the non-responders\n   compared to the responders (p = 0.045). Conclusion. The obtained results\n   indicate that in the first episode of schizophrenia the blood levels of\n   non-specific inflammation markers (WBS, CRP, ESR and Gra from the leukocyte\n   formula) were high in the subpopulation of patients with the tendency towards\n   normalization of inflammation parameters after a 4-week antipsychotic\n   treatment.<\/jats:p>","DOI":"10.2298\/vsp140526016s","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T13:30:48Z","timestamp":1427722248000},"page":"1085-1092","source":"Crossref","is-referenced-by-count":23,"title":["The effect of antipsychotic drugs on nonspecific inflammation markers in the first episode of schizophrenia"],"prefix":"10.2298","volume":"72","author":[{"given":"Vesna","family":"Stefanovic","sequence":"first","affiliation":[{"name":"Clinic for Psychiatric Disorders \u201eDr Laza Lazarevi\u0107\u201c, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Mihajlovic","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milutin","family":"Nenadovic","sequence":"additional","affiliation":[{"name":"Clinic for Psychiatric Disorders \u201eDr Laza Lazarevi\u0107\u201c, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavica","family":"Djukic-Dejanovic","sequence":"additional","affiliation":[{"name":"Clinic for Psychiatric Disorders \u201eDr Laza Lazarevi\u0107\u201c, Belgrade + Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-814X","authenticated-orcid":false,"given":"Milica","family":"Borovcanin","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Kragujevac"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Trajkovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Statistics and Informatics, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:15:00Z","timestamp":1685358900000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501500016S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140526016s","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}