{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:10:16Z","timestamp":1740161416502,"version":"3.37.3"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministry of Education, Science and Technological Development of the Republic of Serbia","doi-asserted-by":"publisher","award":["175092"],"award-info":[{"award-number":["175092"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Bacground\/Aim. Upper urinary tract urothelial carcinoma (UUT-UC) constitutes\n   5% of malignant neoplasms arising from transitional epithelium, but is more\n   invasive than bladder cancer. Lzmphovascular invasion (LVI) is associated\n   with biologically aggressive carcinoma and with occult metastases. The aim of\n   this study was to investigate the correlation between LVI and\n   immunohistochemical expression of two frequently routinely applied\n   immunohistochemical biomarkers, Ki-67 and E-cadherin, in UUT-UC. Methods. The\n   specimens from 106 patients with UUT-UC who had undergone nephroureterectomy\n   were analyzed for pathologic parameters and LVI, while Ki-67 and E-cadherin\n   expression were assessed by immunohistochemistry. Results. Ki-67 was\n   overexpressed in 38% of the cases, while 45% of tumors demonstrated aberrant\n   E-cadherin staining. The presence of LVI was significantly associated with\n   tumor stage, grade, non-papillary growth, nodular invasion pattern, high\n   Ki-67 labeling index and altered E-cadherin expression. Analyzing logistic\n   regression models, we have shown that tumor properties such as stage, grade,\n   growth and invasion pattern (p &lt; 0.001), as well as the expression of Ki-67\n   and E-cadherin (p &lt; 0.001) significantly predicted the presence of LVI. In\n   the first model, only solid tumor architecture (p &lt; 0.05) and nodular\n   invasion pattern (p &lt; 0.05) were significant predictors of LVI. In the second\n   model, Ki-67 expression was found to improve the prediction of LVI (p &lt;\n   0.05). Conslusion. Our results suggest that Ki-67 overexpression is an\n   independent predictor of LVI in UUTUC, indicating the progression of the\n   disease. E-cadherin staining adds no valuable information to LVI probability\n   assessment. This emphasizes the importance of Ki-67 staining of UUT-UC\n   sections in routine pathological practice. Patients with Ki-67\n   overexpression, especially in solid tumors with nodular invasion, should be\n   monitored more closely after surgery.<\/jats:p>","DOI":"10.2298\/vsp140605101s","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T13:00:34Z","timestamp":1443704434000},"page":"982-988","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Ki-67 and E-cadherin expression on lymphovascular invasion in upper urinary tract urothelial carcinoma"],"prefix":"10.2298","volume":"72","author":[{"given":"Slavica","family":"Stojnev","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-297X","authenticated-orcid":false,"given":"Miljan","family":"Krstic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-734X","authenticated-orcid":false,"given":"Ljubinka","family":"Jankovic-Velickovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ristic-Petrovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-2757","authenticated-orcid":false,"given":"Maja","family":"Milojkovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pathophysiology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Anatomy, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Stokanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Pharmacology and Toxicology, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sladjana","family":"Ugrenovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Anatomy, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:15:36Z","timestamp":1685358936000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501500101S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140605101s","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"type":"print","value":"0042-8450"},{"type":"electronic","value":"2406-0720"}],"subject":[],"published":{"date-parts":[[2015]]}}}