{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:19:22Z","timestamp":1785233962666,"version":"3.55.0"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Introduction. Good?s syndrome is a rare cause of adultonset immunodeficiency\n   associated with thymoma. Good?s syndrome should be considered in patients\n   older than 40 years with the history of frequent infections. An abnormal\n   immunoglobulin profile needs further investigation and flow cytometry which\n   is crucial for establishing the diagnosis of Good?s syndrome. Case report. We\n   present a 56- year-old men with Good?s syndrome diagnosed after a twoyear\n   history of recurrent infections. Examination of immune status of the patient\n   showed decreased serum levels of all immunoglobulins. Flow cytometry of\n   peripheral blood lymphocyte revealed markedly reduced peripheral B cells, CD4\n   T-cell lymphopenia, inverted CD4\/CD8 T-cell-ratio 0.37 (CD4 - 20.82%, CD8 -\n   70.7%). Analysis of the subpopulations of T-lymphocytes showed relative\n   increasing ?? T cell receptor (TCR) T lymphocytes. Computed tomography scan\n   of the chest showed a mediastinal mass compatible with thymoma of the\n   diameter of 40 mm. After initiation of intravenous immunoglobulins the\n   patient was in the good clinical condition and without bacterial\n   complications. As the patient refused the operative treatment we continued to\n   control the mediastinal tumor mass which did not increase during a 3-year\n   follow-up. Conclusion. The presented patient had a typical immunological\n   finding for Good?s syndrome, but also the increase in ?? TCR T-lymphocyte\n   subpopulation for which it is difficult to determine whether this is\n   pathogenetic or secondary reactive event.<\/jats:p>","DOI":"10.2298\/vsp140609102t","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T13:00:34Z","timestamp":1443704434000},"page":"1039-1043","source":"Crossref","is-referenced-by-count":3,"title":["Good\u2019s syndrome with increasing \u03b3\u03b4 T-lymphocyte subpopulation: A case report"],"prefix":"10.2298","volume":"72","author":[{"given":"Dragana","family":"Tadic","sequence":"first","affiliation":[{"name":"Clinical Hospital Center \"Be\u017eanijska kosa\", Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"Markovic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center \u201cBe\u017eanijska kosa\u201d Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Kraguljac-Kurtovic","sequence":"additional","affiliation":[{"name":"Clinic of Hematology, Clinical Center of Serbia, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olika","family":"Drobnjak-Tomasek","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center \u201cBe\u017eanijska kosa\u201d, Belgrade"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:15:36Z","timestamp":1685358936000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501500102T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140609102t","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}