{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:59:50Z","timestamp":1777532390517,"version":"3.51.4"},"reference-count":0,"publisher":"National Library of Serbia","issue":"6","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Background\/Aim. Fewer of unknown origin (FUO) remains amongst the most\n   difficult diagnostic dilemmas in contemporary medicine. The aim of this study\n   was to determine the causes of FUO and to identify the methods of diagnosis\n   in patients with FUO in a tertiary care setting in the Republic of Macedonia.\n   Methods. Retrospectively histories of 123 immunocompetent patients older than\n   14 years with classical FUO that had been examined at the University Hospital\n   for Infectious Diseases and Febrile Conditions in the city of Skopje, during\n   the period 2006?2012 were evaluated. FUO was defined as axillary fever of ?\n   37.5?C on several occasions, fever duration of more than 21 days and failure\n   to reach the diagnosis after the initial diagnostic workup comprised of\n   several defined basic investigations. Results. Infections were the cause of\n   FUO in 51 (41.5%) of the patients, followed by non-infective inflammatory\n   disorders (NIID) in 28 (22.8%), miscellaneous in 12 (9.7%) and neoplasm in 11\n   (8.9%) of the patients. Twenty one of the patients (17.1%) remained\n   undiagnosed. The most common causes for FUO were visceral leishmaniasis,\n   abscesses, urinary tract infections, subacute endocarditis, polymyalgia\n   rheumatica and adult onset of Still disease. The final diagnosis was reached\n   with histology in 24 (23.5%), imaging and endoscopic procedures in 21\n   (20.6%), clinical course and empiric therapy response in 20 (19.6%), serology\n   in 18 (17.6%) and cultures in 16 (15.7%) of the cases. Conclusion. In the\n   Republic of Macedonia infections are the leading cause of FUO, predominately\n   visceral leishmaniasis. In the future in patients with prolonged fever,\n   physicians should think more often of this disease, as well as of the\n   possibility of atypical presentation of the common classical causes of FUO.<\/jats:p>","DOI":"10.2298\/vsp140827050b","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T11:54:44Z","timestamp":1458734084000},"page":"553-558","source":"Crossref","is-referenced-by-count":8,"title":["Fever of unknown origin \u2212 diagnostic methods in a European developing country"],"prefix":"10.2298","volume":"73","author":[{"given":"Mile","family":"Bosilkovski","sequence":"first","affiliation":[{"name":"University Hospital for Infectious Diseases and Febrile Conditions, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Dimzova","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases and Febrile Conditions, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-7334","authenticated-orcid":false,"given":"Milena","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases and Febrile Conditions, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Semenakova-Cvetkovska","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases and Febrile Conditions, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Vasileva-Duganovska","sequence":"additional","affiliation":[{"name":"University Hospital for Infectious Diseases and Febrile Conditions, Faculty of Medicine, Ss Cyril and Methodius University, Skopje, Republic of Macedonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:16:50Z","timestamp":1685359010000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501600050B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp140827050b","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}