{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:39:13Z","timestamp":1778924353410,"version":"3.51.4"},"reference-count":0,"publisher":"National Library of Serbia","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Background\/Aim. Recurrent or habitual missed abortions (RMA) are defined as\n   three or more consecutive abortions. In the first trimester of pregnancy\n   habitual missed abortions occur in about 1% of population. The aim of this\n   immunohistochemical study of decidua in RMA of unknown etiology was to\n   identify subpopulations of decidual lymphocytes in recurrent miscarriages and\n   compare the distribution of immunocompetent cells in artificial abortions and\n   RMA. Methods. The study included 30 women with at least 2 consecutive\n   miscarriages in the first trimester of pregnancy. Curettements of the third\n   missed abortion were immunohistochemically analyzed. The control group\n   consisted of 20 women without loaded reproductive anamnesis, with the\n   abortion for social reasons. Criteria for exclusion from the study were\n   diagnosed uterine anomalies, positive screening for thrombophilia and women\n   who suffered from diabetes mellitus and disorders in the function of the\n   thyroid gland. Immunophenotyping was performed by immuno-alkaline phosphatase\n   (APAAP) using monoclonal antibodies: CD 30, CD 45 RO, CD 56 and CD 57, CD 68.\n   Results. The number of missed abortions (1,223) was on the average 9.7% of\n   all deliveriies during the test period. Among them RMA were registered in 52\n   (4.2%) patients and in 30 (57%) the exact etiology of abortions was not\n   determined. RMA was most common in the 25-34 years of age group. The largest\n   number of RMA showed the ultrasound characteristics of missed abortion in 60%\n   of cases and was in nulliparous patients (76.7%). The number of NK CD56\n   positive cells did not differ significantly between the types of abortion. In\n   the decidual tissue, a number of NK CD57 positive cells was significantly\n   higher in missed abortions compared to artificial interruptions (p &lt; 0.01).\n   In artificial termination of pregnancy there was an absolute predominance of\n   CD45RO lymphocyte subpopulations, whereas in the RMA group there was slightly\n   greater predominance of CD30 positive cells. The completed analysis showed a\n   significantly higher number of CD68 positive macrophages in a decidual tissue\n   of RMA pregnancy (p &lt; 0.01). Conclusion. The number and phenotypic structure\n   of NK cells are significantly different in normal pregnancy decidua and in\n   RMA. The NK cell dominance is present in the RMA group, in favor of CD56+ and\n   CD 57 of subpopulations with increased CD30 of T lymphocyte subpopulations.\n   Macrophages are more numerous in the decidua of pregnancies ended in\n   abortion, so the cause to RMA of unknown etiology in a number of cases could\n   be disregulation of immunocompetent cells.<\/jats:p>","DOI":"10.2298\/vsp141226018r","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T15:54:26Z","timestamp":1455724466000},"page":"306-311","source":"Crossref","is-referenced-by-count":7,"title":["The structure of immunocompetent decidual cells in recurrent missed abortions"],"prefix":"10.2298","volume":"73","author":[{"given":"Dragana","family":"Radovic-Janosevic","sequence":"first","affiliation":[{"name":"Clinical Center Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmina","family":"Popovic","sequence":"additional","affiliation":[{"name":"Clinical Center Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-297X","authenticated-orcid":false,"given":"Miljan","family":"Krstic","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Clinical Center Ni\u0161, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Tubic-Pavlovic","sequence":"additional","affiliation":[{"name":"Clinical Center Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Stefanovic","sequence":"additional","affiliation":[{"name":"Clinical Center Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Pop-Trajkovic","sequence":"additional","affiliation":[{"name":"Clinical Center Ni\u0161, Clinic of Gynecology and Obstetrics, Ni\u0161"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:16:37Z","timestamp":1685358997000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501600018R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp141226018r","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}