{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:22:57Z","timestamp":1780730577391,"version":"3.54.1"},"reference-count":0,"publisher":"National Library of Serbia","issue":"11","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Background\/Aim. Pregnancy is defined as a condition of increased oxidative stress. The aim of this research was to determine the intensity of pro-oxidative processes and the content of GSH, as well as antioxidative enzymes: superoxide dismutase (SOD), catalase (CAT), gluthatione peroxidase (GSH-Px), and the total antioxidative status (TAS) in patients with spontaneous abortions. Methods. A total of 120 patients were involved in the research (70 spontaneous abortions and 50 healthy pregnancies). The patients were divided into groups: 35 patients with incomplete and complete spontaneous abortion (group S), 35 patients with missed abortion (group M) and a control group of 50 healthy pregnancies (group N), all of them being in the first trimester of pregnancy. The intensity of lipid proxidation (LPx) was determined with a modified thyobarbituric acid method. The GSH content in erythrocytes was determined by the method ba-sed on the amount of non-protein sulfhydryl residues using the Ellman's reagens. The following antioxidative parameters in the blood were measured: SOD ? by the method with xanthine oxidase-using commercial RANSOD sets; CAT ? by the method of Aebi (the enzyme activity was measured by monitoring the decomposition of H2O2 at 240 nm); GSH-Px was determined using hydrogen peroxide as a substrate. The TAS was determined using the ferric reducing autioxidant potential (FRAP) met-hod. Results. The highest average value of LPx was recorded in the spontaneous abortion group (48.03 pmoL\/mg Hgb), and the lowest value was recorded in the control group (26.06 pmoL\/mg Hgb). A statistically significant positive correlation between LPx and CAT in the group of patients with missed abortion was also noted (p &lt; 0.05, r = 0.37). There was a statistically highly significant difference (p &lt; 0.001) in SOD and in CAT activitices be-tween the examined patients (groups S and N) and the control group (Student?s t-test and ANOVA). The highest average value of TAS was recorded in the group S (710.39 ?mol\/L), while the value in the group M was 277.66 ?mol\/L. The average value of TAS in the control group was 452.12 ?mol\/L. Student?s t-test showed a statistically highly significant difference in the values of TAS between the examined patients (groups S and M) and the control group. Conclusion. Determination of the value of pro-oxidative and antioxidative parameters in patients with sponta-neous abortion can be the indicator of condition of fetoplacental unit and these analyses can be included in the protocol of the rutine perinatal diagnostics.<\/jats:p>","DOI":"10.2298\/vsp150321123g","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T13:13:49Z","timestamp":1464268429000},"page":"1038-1043","source":"Crossref","is-referenced-by-count":4,"title":["Disturbance of oxidative balance in the first trimester of spontaneous abortions"],"prefix":"10.2298","volume":"73","author":[{"given":"Zorica","family":"Grujic","sequence":"first","affiliation":[{"name":"Clinical Centre of Vojvodina, Faculty of Medicine, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilija","family":"Grujic","sequence":"additional","affiliation":[{"name":"Private Gynecological Hospital \u201cFemina\u201d, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-3060","authenticated-orcid":false,"given":"Mirjana","family":"Bogavac","sequence":"additional","affiliation":[{"name":"Clinical Centre of Vojvodina, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-3896","authenticated-orcid":false,"given":"Aleksandra","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacy, Novi Sad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radoslav","family":"Mitic","sequence":"additional","affiliation":[{"name":"Medical Faculty, Kosovska Mitrovica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Stajic","sequence":"additional","affiliation":[{"name":"Insititute for Health Protection of the Ministry of Interior, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:17:22Z","timestamp":1685359042000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501600123G"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp150321123g","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}