{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T04:11:21Z","timestamp":1685419881191},"reference-count":0,"publisher":"National Library of Serbia","issue":"10","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["VSP","VOJNOSANIT PREGL","VOJNOSANITETSKI PREG"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Introduction. Turner syndrome presents with one of the most frequent\n   chromosomal aberrations in female, typically presented with growth\n   retardation, ovarian insufficiency, facial dysmorphism, and numerous other\n   somatic stigmata. Gigantism is an extremely rare condition resulting from an\n   excessive growth hormone (GH) secretion that occurs during childhood before\n   the fusion of epiphyseal growth plates. The major clinical feature of\n   gigantism is growth acceleration, although these patients also suffer from\n   hypogonadism and soft tissue hypertrophy. Case report. We presented a girl\n   with mosaic Turner syndrome, delayed puberty and normal linear growth for the\n   sex and age, due to the simultaneous GH hypersecretion by pituitary tumor. In\n   the presented case all the typical phenotypic stigmata related to Turner\n   syndrome were missing. Due to excessive pituitary GH secretion during the\n   period while the epiphyseal growth plates of the long bones are still open,\n   characteristic stagnation in longitudinal growth has not been demonstrated.\n   The patient presented with delayed puberty and primary amenorrhea along with\n   a sudden appearance of clinical signs of hypersomatotropinism, which were the\n   reasons for seeking medical help at the age of 16. Conclusion. Physical\n   examination of children presenting with delayed puberty but without growth\n   arrest must include an overall hormonal and genetic testing even in the cases\n   when typical clinical presentations of genetic disorder are absent. To the\n   best of our knowledge, this is the first reported case of simultaneous\n   presence of Turner syndrome and gigantism in the literature.<\/jats:p>","DOI":"10.2298\/vsp150620014d","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T11:49:50Z","timestamp":1454586590000},"page":"961-966","source":"Crossref","is-referenced-by-count":0,"title":["Coexisting diseases modifying each other\u2019s presentation - lack of growth failure in Turner syndrome due to the associated pituitary gigantism"],"prefix":"10.2298","volume":"73","author":[{"given":"Tamara","family":"Dragovic","sequence":"first","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorana","family":"Djuran","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Jelic","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center \u201cBe\u017eanijska kosa\u201d, Clinic for Internal Medicine, Department of Endocrinology, Belgrade + Faculty of Medicine, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasa","family":"Kikovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snezana","family":"Kuzmic-Jankovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Hajdukovic","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Clinic for Endocrinology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1078","container-title":["Vojnosanitetski pregled","Military Medical and Pharmaceutical Journal of Serbia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:16:35Z","timestamp":1685358995000},"score":1,"resource":{"primary":{"URL":"https:\/\/doiserbia.nb.rs\/Article.aspx?ID=0042-84501600014D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.2298\/vsp150620014d","relation":{},"ISSN":["0042-8450","2406-0720"],"issn-type":[{"value":"0042-8450","type":"print"},{"value":"2406-0720","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}