{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:11:50Z","timestamp":1777554710860,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Contact allergy to and allergic contact dermatitis from methyldibromoglutaronitrile (MDBGN) have been frequently reported since the 1990s.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      <jats:bold>This study was initiated to help determine the optimal test preparation for MDBGN and to help determine the clinical relevance of such a contact allergy.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      <jats:bold>In 38 patients with positive (32 patients) or doubtful (6 patients) patch-test reactions to at least one of four test preparations of MDBGN in petrolatum at 1.0%, 0.5%, 0.3%, and 0.1% (all weight per weight [w\/w]), a repeated open application test (ROAT) with moisturizers with and without MDBGN at 0.03% w\/w was conducted on patients' upper arms for a maximum of 4 weeks. Seven patients not hypersensitive to MDBGN served as controls and went through the same procedure.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        Nineteen (59.4%) of the 32 MDBGN-allergic patients developed a positive ROAT result on the arm on which the moisturizer containing MDBGN was applied whereas no patients with doubtful or negative reactions to MDBGN reacted (\n                        <jats:italic toggle=\"yes\">p<\/jats:italic>\n                        = .002). A statistically significant association was found between the patch-test reactivity and the outcome of the ROAT (\n                        <jats:italic toggle=\"yes\">p<\/jats:italic>\n                        &lt; .001).\n                      <\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      <jats:bold>Patch testing with MDBGN at 0.3% and 0.1% will miss clinically relevant patch-test reactions to MDBGN.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/6620.2007.06042","type":"journal-article","created":{"date-parts":[[2008,2,14]],"date-time":"2008-02-14T16:59:41Z","timestamp":1203008381000},"page":"203-207","source":"Crossref","is-referenced-by-count":8,"title":["Repeated Open Application Tests with Methyldibromoglutaronitrile in Dermatitis Patients with and without Hypersensitivity to Methyldibromoglutaronitrile"],"prefix":"10.1177","volume":"18","author":[{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Gruvberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"e_1_3_1_2_2","first-page":"45","article-title":"Kontaktallergie auf einen neuen Konservierungsstoff","volume":"37","author":"Senff H","year":"1989","unstructured":"Senff H, , Exner M, , G\u00f6rtz J, , Goos M. 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