{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:13:15Z","timestamp":1777723995296,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endothelial dysfunction is useful in predicting future cardiovascular disease. At present several tests are available to test endothelial function: coronary diameter response to acetylcholine, forearm bloodflow (FBF) response to acetylcholine, and brachial artery flow-mediated dilative (FMD) response to postischemic hyperemia. This study aimed to compare the three most frequently reported endothelial function tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-eight patients (19 males and nine females, mean age 57 years) referred for diagnostic coronary angiography were considered for endothelial function measurement in the coronary artery as well as in the forearm by FBF and FMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acetylcholine decreased the mean coronary diameter by 7.4% (SD 6.3%) and increased the mean FBF by 230% (SD 152%). Hyperemia increased the mean brachial diameter by 6.7% (SD 4.8%). The effect of acetylcholine on forearm resistance vessels was significantly related to the effect of acetylcholine on the coronary conduit vessels ( P=0.039). Nonetheless, FMD was not related to FBF nor to the coronary response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with mild coronary endothelial dysfunction, forearm vasoreactivity is related to the coronary response, provided that the same stimulus is used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/6650.2002.33513","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T15:55:13Z","timestamp":1187020513000},"page":"19-24","source":"Crossref","is-referenced-by-count":27,"title":["Endothelial Dysfunction in Patients with Coronary Artery Disease: A Comparison of Three Frequently Reported Tests"],"prefix":"10.1177","volume":"50","author":[{"given":"Stefan H. J.","family":"Monnink","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul L.","family":"Van Haelst","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad J.","family":"Van Boven","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik S. G.","family":"Stroes","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Hospital Utrechtthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 A.","family":"Tio","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thijs W. M.","family":"Plokker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Antonius Hospital Nieuwegein, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andries J.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Thoraxcenter, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nic J. G. M.","family":"Veeger","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry J. G. M.","family":"Crijns","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiek H.","family":"Van Gilst","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, University Hospital Groningenthe Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"bibr1-6650.2002.33513","first-page":"3527","volume":"91","author":"Cines DB","year":"1998","journal-title":"Blood"},{"key":"bibr2-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.9.948"},{"key":"bibr3-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"bibr4-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"bibr5-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.320"},{"key":"bibr6-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.5.1314"},{"key":"bibr7-6650.2002.33513","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00327-4"},{"key":"bibr8-6650.2002.33513","first-page":"1747","volume":"95","author":"Quyyumi AA","year":"1995","journal-title":"Impact of risk factors for coronary atherosclerosis. 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