{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:59:22Z","timestamp":1789595962286,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>This retrospective chart review examines the safety of high-dose (\u2265 15\n                        U\/kg body weight or \u2265 800 total units) botulinum toxin type A (BOTOX,\n                        Allergan Inc., Irvine, CA) in children and young adults with spasticity.\n                        Ninety-four children weighing &lt; 45 kg received a mean total dose of 334.1\n                        U or 19.1 U\/kg. Fourteen young adults weighing \u2265 45 kg received a mean total\n                        dose of 927.3 U or 15.2 U\/kg. Adverse events were reported by 3 of the 108\n                        patients (2.8%) and included single instances of rash and enuresis. The only\n                        serious adverse event consisted of mild, generalized botulism in a\n                        13-year-old patient who received a 23 U\/kg dose to the hamstrings and\n                        gastrocnemius\/soleus bilaterally. No serious adverse events were noted in\n                        children weighing &lt; 45 kg who received botulinum toxin type A doses of 15\n                        to 22 U\/kg of body weight or in young adults \u2265 45 kg who received total\n                        doses of 800 to 1200 U in a single injection protocol. High-dose botulinum\n                        toxin type A is safe for the treatment of spasticity in children and young\n                        adults. 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