{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:50:48Z","timestamp":1777884648771,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:p>\n                    The purpose of this study was to assess the relationship of mammographic breast density (BD) and cell proliferation\/focal adhesion kinase activation\u2013seeking radiotracer technetium 99m pentavalent dimercaptosuccinic acid (\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA) uptake in women with different breast histologies, that is, mild epithelial hyperplasia (MEH), florid epithelial hyperplasia (FEH), mixed ductal carcinoma in situ with invasive ductal carcinoma (DCIS + IDC), and pure IDC. Fifty-five women with histologically confirmed mammary pathologies were submitted preoperatively to mammography and\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA scintimammography. The percentage and intensity of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA uptake and the percentage of BD were calculated by computer-assisted methods and compared ( t-test) between the breast pathologies. In breasts with increased BD, FEH and DCIS + IDC were found. On the contrary, pure IDC and MEH were identified in breasts with significantly lower BD values. In breasts with increased\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA area and intensity of uptake, FEH was the main lesion found compared to all other histologies. Linear regression analysis between BD and\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA uptake area and intensity revealed significant coefficients of correlation ( r = .689, p &lt; .001 and r = .582, p &lt; .001, respectively). Increased BD correlates with the presence of FEH and mixed DCIS + IDC but not with pure IDC or MEH. Its close relationship to\n                    <jats:sup>99m<\/jats:sup>\n                    Tc(V)-DMSA, which also showed an affinity to FEH, indicates that stromal microenvironment may constitute a specific substrate leading to progression to different subtypes of cancerous lesions originating from different pathways.\n                  <\/jats:p>","DOI":"10.2310\/7290.2010.00056","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T12:18:12Z","timestamp":1520252292000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased Breast Density Correlates with the Proliferation-Seeking Radiotracer\n                    <sup>99m<\/sup>\n                    Tc(V)-DMSA Uptake in Florid Epithelial Hyperplasia and in Mixed Ductal Carcinoma in Situ with Invasive Ductal Carcinoma but Not in Pure Invasive Ductal Carcinoma or in Mild Epithelial Hyperplasia"],"prefix":"10.1177","volume":"10","author":[{"given":"Vassilios","family":"Papantoniou","sequence":"first","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pipitsa","family":"Valsamaki","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Sotiropoulou","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Tsaroucha","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Tsiouris","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Sotiropoulou","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spyridon","family":"Marinopoulos","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Kounadi","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore","family":"Karianos","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Fothiadaki","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Archontaki","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Syrgiannis","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Ptohis","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Makris","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Limouris","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Antsaklis","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine, Pathology, Obstetrics and Gynecology, and Radiology, \u201cAlexandra\u201d University Hospital; Department of Radiology, \u201cSotiria\u201d General Hospital; and Department of Nuclear Medicine Department, Areteion University Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"bibr1-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1260"},{"key":"bibr2-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3368"},{"key":"bibr3-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"bibr4-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1507"},{"key":"bibr5-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.4.637"},{"key":"bibr6-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0394"},{"key":"bibr7-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880115)61:2<266::AID-CNCR2820610212>3.0.CO;2-N"},{"key":"bibr8-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.244"},{"key":"bibr9-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1304"},{"key":"bibr10-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971115)80:10<1945::AID-CNCR11>3.0.CO;2-Y"},{"key":"bibr11-7290.2010.00056","first-page":"2867","volume":"5","author":"Heffelfinger SC","year":"1999","journal-title":"Clin Cancer Res"},{"key":"bibr12-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80120-6"},{"key":"bibr13-7290.2010.00056","first-page":"773","volume":"2","author":"Bhardwaj B","year":"1996","journal-title":"Clin Cancer Res"},{"key":"bibr14-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800767105"},{"key":"bibr15-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3180337792"},{"key":"bibr16-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.4137\/117739010700200001"},{"key":"bibr17-7290.2010.00056","first-page":"323","volume":"25","author":"Ohta H","year":"1984","journal-title":"J Nucl Med"},{"key":"bibr18-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200205000-00006"},{"key":"bibr19-7290.2010.00056","first-page":"1741","volume":"38","author":"Hirano T","year":"1997","journal-title":"J Nucl Med"},{"key":"bibr20-7290.2010.00056","first-page":"202","volume":"36","author":"Hirano T","year":"1995","journal-title":"J Nucl Med"},{"key":"bibr21-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1629830"},{"key":"bibr22-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199710000-00003"},{"key":"bibr23-7290.2010.00056","first-page":"100","volume":"35","author":"Babbar A","year":"1991","journal-title":"J Nucl Biol Med"},{"key":"bibr24-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199202000-00011"},{"key":"bibr25-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(97)00110-X"},{"key":"bibr26-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-005-1773-4"},{"key":"bibr27-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1334-7"},{"key":"bibr28-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr751"},{"key":"bibr29-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnm.0000243367.73141.85"},{"key":"bibr30-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr948"},{"key":"bibr31-7290.2010.00056","first-page":"554","volume":"47","author":"Papantoniou V","year":"2006","journal-title":"J Nucl Med"},{"key":"bibr32-7290.2010.00056","first-page":"1133","volume":"7","author":"Boyd NF","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"bibr33-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm062"},{"key":"bibr34-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21624"},{"key":"bibr35-7290.2010.00056","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1655"},{"key":"bibr36-7290.2010.00056","doi-asserted-by":"crossref","unstructured":"Papantoniou V, Sotiropoulou E, Valsamaki P, Breast density, scintimammographic (99m)Tc(V)DMSA uptake, and calcitonin gene related peptide (CGRP) expression in mixed invasive ductal associated with extensive in situ ductal carcinoma (IDC + DCIS) and pure invasive ductal carcinoma (IDC): correlation with estrogen receptor (ER) status, proliferation index Ki-67, and histological grade. 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