{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:51:17Z","timestamp":1777884677088,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Imaging"],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>\n                    Molecular imaging probes can target abnormal gene expression patterns in patients and allow early diagnosis of disease. For selecting a suitable imaging probe, the current Molecular Imaging and Contrast Agent Database (MICAD) provides descriptive and qualitative information on imaging probe characteristics and properties. However, MICAD does not support linkage with the expression profiles of target genes. The proposed Disease-specific Imaging Probe Profiling (DIPP) database quantitatively archives and presents the gene expression profiles of targets across different diseases, anatomic regions, and subcellular locations, providing an objective reference for selecting imaging probes. The DIPP database was validated with a clinical positron emission tomography (PET) study on lung cancer and an in vitro study on neuroendocrine cancer. The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of\n                    <jats:sup>11<\/jats:sup>\n                    C-choline and [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoro-2- deoxy-2-D-glucose (FDG), respectively. Their significant overexpressions corresponded to the findings that the uptake rate of FDG increased with tumor size but that of\n                    <jats:sup>11<\/jats:sup>\n                    C-choline remained constant. Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe. A Web search tool of the DIPP database is available at http:\/\/www.polyu.edu.hk\/bmi\/dipp\/ .\n                  <\/jats:p>","DOI":"10.2310\/7290.2014.00017","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T12:23:49Z","timestamp":1520252629000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease-Specific Target Gene Expression Profiling of Molecular Imaging Probes: Database Development and Clinical Validation"],"prefix":"10.1177","volume":"13","author":[{"given":"Lawrence Wing-Chi","family":"Chan","sequence":"first","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie Hiu-Ching","family":"Ngo","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moss Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Zhao","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Ka-Wai","family":"Law","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze Chuen Cesar","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Yat-Ming","family":"Yung","sequence":"additional","affiliation":[{"name":"From the Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"bibr1-7290.2014.00017","first-page":"4","volume":"47","author":"Lamerichs R","year":"2003","journal-title":"Medica Mundi"},{"key":"bibr2-7290.2014.00017","volume-title":"Molecular imaging radiopharmaceuticals for PET and SPECT","author":"Vallabhajosula S","year":"2009"},{"key":"bibr3-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1012"},{"key":"bibr4-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-98074-2"},{"issue":"1","key":"bibr5-7290.2014.00017","first-page":"16","volume":"6","author":"Menezes GA","year":"2011","journal-title":"Internet J Med Update"},{"key":"bibr6-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0545-z"},{"key":"bibr7-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090585"},{"key":"bibr8-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-10853-2_12"},{"key":"bibr9-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.12.036"},{"key":"bibr10-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.053"},{"key":"bibr11-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-77496-9_8"},{"key":"bibr12-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.026"},{"key":"bibr13-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292030807"},{"key":"bibr14-7290.2014.00017","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2362041876"},{"key":"bibr15-7290.2014.00017","unstructured":"National Center for Biotechnology Information. 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