{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:55:58Z","timestamp":1779886558514,"version":"3.53.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Infliximab, a tumor necrosis factor \u03b1 antagonist, has recently been shown to be successful for the short-term treatment of generalized pustular psoriasis (GPP) in multiple case reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The goal of this case series was to assess the efficacy of the longer-term management of GPP with infliximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Three patients with severe GPP were followed to assess the efficacy of long-term treatment with infliximab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Infliximab therapy was more efficacious with infusion every 6 to 8 weeks in combination with methotrexate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Infliximab may be efficacious for some patients for the long-term management of GPP. Maintaining a strict infliximab infusion schedule and concomitant methotrexate therapy may decrease infusion reactions and increase efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2008.07036","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"184-188","source":"Crossref","is-referenced-by-count":17,"title":["Long-Term Management of Generalized Pustular Psoriasis with Infliximab: Case Series"],"prefix":"10.1177","volume":"12","author":[{"given":"Shannon B.","family":"Routhouska","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, and Department of Dermatology, University of Cincinnati Medical Center, Cincinnati, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav B.","family":"Sheth","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, and Department of Dermatology, University of Cincinnati Medical Center, Cincinnati, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Korman","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Murdough Family Center for Psoriasis, University Hospitals of Cleveland, Case Medical Center, Cleveland, OH, and Department of Dermatology, University of Cincinnati Medical Center, Cincinnati, 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