{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:43:23Z","timestamp":1777513403312,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Historically, patients with the consumptive coagulopathy Kasabach-Merritt syndrome (KMS) have been treated with systemic corticosteroids as first-line therapy, but many patients do not respond. Recently, there have been increasing reports of the use of the chemotherapeutic drug vincristine in these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report a case of a newborn with a kaposiform hemangioendothelioma (KHE) of the right leg associated with KMS treated successfully with vincristine and oral corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The patient's chart and the literature on the subject were reviewed using\n                      <jats:italic toggle=\"yes\">Medline<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">PubMed.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"results\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Treatment with vincristine and corticosteroids lead to sustained shrinking of the tumor and correction of the thrombocytopenia and coagulopathy through 1 year of age. We believe this is the first report in the North American literature of corticosteroids and vincristine being used concomitantly as first-line therapy for KHE with KMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"conclusions\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vincristine and corticosteroids should be considered first-line treatment for KMS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2008.08006","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"155-159","source":"Crossref","is-referenced-by-count":26,"title":["Vincristine and Corticosteroids as First-Line Treatment of Kasabach-Merritt Syndrome in Kaposiform Hemangioendothelioma"],"prefix":"10.1177","volume":"13","author":[{"given":"Aaron M.","family":"Drucker","sequence":"first","affiliation":[{"name":"From the Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children and the University of Toronto, Toronto, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Pope","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children and the University of Toronto, Toronto, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Mahant","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children and the University of Toronto, Toronto, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Weinstein","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children and the University of Toronto, Toronto, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,5]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(88)80135-0"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01302.x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01796.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02453.x"},{"key":"e_1_3_1_6_2","first-page":"U2418","article-title":"Vincristine for the treatment of Kasabach-Merritt syndrome: Recent New Zealand case experience","volume":"120","author":"Thomson K","year":"2007","unstructured":"Thomson K, Pinnock R, Teague L, . Vincristine for the treatment of Kasabach-Merritt syndrome: Recent New Zealand case experience. N Z Med J 2007;120:U2418.","journal-title":"N Z Med J"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200208000-00010"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70249-X"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199304000-00001"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200405000-00001"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/120347540200600405"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100240010110"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199711000-00001"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00595897"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000184310.60701.c6"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90130-0"},{"key":"e_1_3_1_17_2","unstructured":"Canadian Pharmacists Association. Vincristine [product monograph]. Available at: http:\/\/www.e-cps.ca (Accessed May 4 2008)."}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2008.08006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2008.08006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2008.08006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:48:19Z","timestamp":1777391299000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2008.08006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.2310\/7750.2008.08006"],"URL":"https:\/\/doi.org\/10.2310\/7750.2008.08006","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}