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Traditional treatments for nail psoriasis, which include topical, intralesional, and oral therapies, may be time-consuming, painful, or unsafe when administered long term. Biologic therapies have demonstrated efficacy for plaque psoriasis and psoriatic arthritis; these therapies may be particularly promising for the treatment of nail psoriasis as both groups of patients have an elevated incidence of nail dystrophy. The biologic therapies adalimumab, alefacept, efalizumab, etanercept, and infliximab have demonstrated clinically important nail psoriasis improvements using the Nail Psoriasis Severity Index, a helpful tool that, upon validation, will allow comparison across treatments and trials. Large-scale, long-term trials using standardized outcome measures are needed to further evaluate biologic therapies for the treatment of nail psoriasis.<\/jats:p>","DOI":"10.2310\/7750.2009.00027","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"S102-S106","source":"Crossref","is-referenced-by-count":18,"title":["Psoriatic Nail Disease: Quality of Life and Treatment"],"prefix":"10.1177","volume":"13","author":[{"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"From the Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Mediprobe Research, Incorporated, London, ON"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"bibr1-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122755"},{"key":"bibr2-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06576.x"},{"key":"bibr3-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)01870-X"},{"key":"bibr4-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06893.x"},{"key":"bibr5-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(05)70199-8"},{"key":"bibr6-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1159\/000246274"},{"key":"bibr7-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-002-0143-0"},{"key":"bibr8-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.07.042"},{"key":"bibr9-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.3.226"},{"key":"bibr10-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh198"},{"key":"bibr11-7750.2009.00027","first-page":"113","volume":"186","author":"Lavaroni G","year":"1994","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"bibr12-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00663.x"},{"key":"bibr13-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.073"},{"key":"bibr14-7750.2009.00027","first-page":"1452","volume":"33","author":"Cassell S","year":"2006","journal-title":"J Rheumatol"},{"key":"bibr15-7750.2009.00027","first-page":"421","volume":"66","author":"van den Bosch F","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"bibr16-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00910-1"},{"key":"bibr17-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.101"},{"key":"bibr18-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01783.x"},{"key":"bibr19-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.748"},{"key":"bibr20-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.09.012"},{"key":"bibr21-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08686.x"},{"key":"bibr22-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67566-6"},{"key":"bibr23-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02305.x"},{"key":"bibr24-7750.2009.00027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02389.x"},{"key":"bibr25-7750.2009.00027","first-page":"339","volume":"5","author":"Parrish CA","year":"2006","journal-title":"J Drugs Dermatol"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2009.00027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2009.00027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2009.00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:48:29Z","timestamp":1777391309000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2009.00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":25,"journal-issue":{"issue":"5_suppl","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.2310\/7750.2009.00027"],"URL":"https:\/\/doi.org\/10.2310\/7750.2009.00027","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}