{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:44:42Z","timestamp":1777513482825,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pityriasis rubra pilaris (PRP) has unknown etiology and is often refractory to conventional therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To document a PRP patient's response to adalimumab therapy and to highlight the potential role of tumor necrosis factor (TNF) in the development of PRP skin lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A patient received adalimumab therapy at standard dosing intervals. In addition, the messenger ribonucleic acid (mRNA) of TNF in the lesional and perilesional normal skin was quantified in two patients with PRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The patient responded to adalimumab therapy and achieved clinical remission by 4 months. There was a significant elevation of TNF mRNA in the lesional skin of PRP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>TNF upregulation is detected in PRP lesional skin, consistent with the observed clinical efficacy of TNF blockade for the treatment of PRP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2010.09023","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"185-188","source":"Crossref","is-referenced-by-count":19,"title":["Type I Pityriasis Rubra Pilaris: Upregulation of Tumor Necrosis Factor \u03b1 and Response to Adalimumab Therapy"],"prefix":"10.1177","volume":"14","author":[{"given":"Yao-Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Ball","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Wan","family":"Su","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Zhong","family":"Zheng","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Skin Science and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"bibr1-7750.2010.09023","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.4.423"},{"key":"bibr2-7750.2010.09023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2006.00247.x"},{"key":"bibr3-7750.2010.09023","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0308"},{"key":"bibr4-7750.2010.09023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.037"},{"key":"bibr5-7750.2010.09023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1468-3083.2007.02282.x","volume":"22","author":"Ruzzetti M","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"bibr6-7750.2010.09023","doi-asserted-by":"crossref","unstructured":"Barth D, Harth W, Treudler R, Successful treatment of pityriasis rubra pilaris (type 1) under combination of infliximab and methotrexate. 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