{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:59:36Z","timestamp":1791251976238,"version":"4.1.0"},"reference-count":127,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Whereas several literature reviews have discussed the role of excipients in drug-related reactions, no article has focused specifically on those found in oral dermatologic medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The Compendium of Pharmaceuticals and Specialties (CPS) was used to reference the inert ingredients found in oral dermatologic medications. An extensive literature review was subsequently conducted using PubMed and MEDLINE to document adverse reactions to these excipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-three oral dermatologie medications were reviewed. Lactose was commonly used as a filler. Several medications indicated that they were dye, tartrazine, or gluten free. Three medications were found to contain soybean oil and one was found to contain peanut oil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Although there are documented reactions to excipients in other products in the literature, few reports outline reactions to excipients in oral dermatologie medications. Whether this low frequency is accurate or whether it is due to a lack of reporting remains unknown. If the latter reasoning is correct, dermatologists must be more aware of these possible reactions. This article serves as a reference guide for dermatologists to aid in prescribing medications to individuals with known sensitivities and to assist in working up patients with suspected reactions to inert ingredients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2010.09027","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"105-114","source":"Crossref","is-referenced-by-count":2,"title":["Are Excipients Really Inert Ingredients? A Review of Adverse Reactions to Excipients in Oral Dermatologic Medications in Canada"],"prefix":"10.1177","volume":"14","author":[{"given":"Kristin","family":"Noiles","sequence":"first","affiliation":[{"name":"From the Michael G. DeGroote School of Medicine, Faculty of Medicine, McMaster University, Hamilton, ON"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Vender","sequence":"additional","affiliation":[{"name":"From the Michael G. DeGroote School of Medicine, Faculty of Medicine, McMaster University, Hamilton, ON"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,5,1]]},"reference":[{"key":"bibr1-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1996.0120"},{"key":"bibr2-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(98)00101-3"},{"key":"bibr3-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(03)00079-X"},{"key":"bibr4-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2000.1421"},{"key":"bibr5-7750.2010.09027","first-page":"93","volume":"1","author":"Smith JM","year":"1982","journal-title":"Adv Drug React Ac Pois Rev"},{"key":"bibr6-7750.2010.09027","volume-title":"Adverse reactions to drug formulation agents: a handbook of excipients","author":"Weiner M","year":"1989"},{"key":"bibr7-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1542\/peds.91.5.927"},{"key":"bibr8-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200204060-00004"},{"key":"bibr9-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1542\/peds.87.3.352"},{"key":"bibr10-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1007\/BF02771765"},{"key":"bibr11-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.2.268"},{"key":"bibr12-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/000992289603500903"},{"key":"bibr13-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90116-7"},{"key":"bibr14-7750.2010.09027","volume-title":"Compendium of pharmaceuticals and specialties (CPS)","author":"Canadian Pharmacists Association","year":"2008"},{"key":"bibr15-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb08014.x"},{"key":"bibr16-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90080-0"},{"key":"bibr17-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(72)90004-8"},{"key":"bibr18-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630010029005"},{"key":"bibr19-7750.2010.09027","first-page":"81","volume":"46","author":"Desmond RE","year":"1981","journal-title":"Ann Allergy"},{"key":"bibr20-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1984.tb02194.x"},{"key":"bibr21-7750.2010.09027","first-page":"28","volume":"41","author":"Trautlein JJ","year":"1978","journal-title":"Ann Allergy"},{"key":"bibr22-7750.2010.09027","first-page":"206","volume":"38","author":"Lockey SD","year":"1977","journal-title":"Ann Allergy"},{"key":"bibr23-7750.2010.09027","first-page":"461","volume":"29","author":"Lockey SD","year":"1971","journal-title":"Ann Allergy"},{"key":"bibr24-7750.2010.09027","volume":"4","author":"Ram FS","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr25-7750.2010.09027","first-page":"7","volume":"48","author":"Criep LH","year":"1971","journal-title":"J Allergy"},{"key":"bibr26-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1159\/000249391"},{"key":"bibr27-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(76)90004-X"},{"key":"bibr28-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1976.tb01889.x"},{"key":"bibr29-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(67)90099-8"},{"key":"bibr30-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90092-5"},{"key":"bibr31-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(67)90076-7"},{"key":"bibr32-7750.2010.09027","first-page":"18","volume":"9","author":"Food Drug Administration","year":"1979","journal-title":"FDA Drug Bull"},{"key":"bibr33-7750.2010.09027","first-page":"910","volume":"126","author":"MacCara ME","year":"1982","journal-title":"Can Med Assoc J"},{"key":"bibr34-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90423-X"},{"key":"bibr35-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(67)90099-8"},{"key":"bibr36-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90080-0"},{"key":"bibr37-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90045-Q"},{"key":"bibr38-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530200025008"},{"key":"bibr39-7750.2010.09027","first-page":"7","volume":"25","author":"Vesely B","year":"1985","journal-title":"Rev Fr Allergol"},{"key":"bibr40-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-72-4-549"},{"key":"bibr41-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01532.x"},{"key":"bibr42-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1975.tb05324.x"},{"key":"bibr43-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb03017.x"},{"key":"bibr44-7750.2010.09027","first-page":"39","volume":"46","author":"Sarkany I","year":"1961","journal-title":"Trans St Johns Hosp Dermatol Soc"},{"key":"bibr45-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.2500\/108854199778251816"},{"key":"bibr46-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(91)32165-1"},{"key":"bibr47-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-198902930-00011"},{"key":"bibr48-7750.2010.09027","first-page":"797","volume":"75","author":"Feingold BF","year":"1975","journal-title":"Am J Nurs"},{"key":"bibr49-7750.2010.09027","first-page":"S227","volume":"92","author":"Bellisle F","year":"2004","journal-title":"Br J Nurs"},{"key":"bibr50-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00913.x"},{"key":"bibr51-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1981.52.1.307"},{"key":"bibr52-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780310114012"},{"key":"bibr53-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.2.119"},{"key":"bibr54-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1984.tb04406.x"},{"key":"bibr55-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/002221948301600604"},{"key":"bibr56-7750.2010.09027","first-page":"275","volume":"48","author":"Ribon A","year":"1982","journal-title":"Ann Allergy"},{"key":"bibr57-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/002221948301600602"},{"key":"bibr58-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(69)90240-0"},{"key":"bibr59-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03150150068019"},{"key":"bibr60-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1977.03270420062018"},{"key":"bibr61-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630100088035"},{"key":"bibr62-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.07054"},{"key":"bibr63-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010100051021"},{"key":"bibr64-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(80)90028-6"},{"key":"bibr65-7750.2010.09027","volume-title":"Cutaneous drug reactions. an integral synopsis of today's systemic drugs","author":"Zurcher K","year":"1992","edition":"2"},{"key":"bibr66-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650430151028"},{"key":"bibr67-7750.2010.09027","first-page":"1908","volume":"141","author":"Osterhalle O","year":"1979","journal-title":"Ogeskr Laeger"},{"key":"bibr68-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8201000214"},{"key":"bibr69-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb06802.x"},{"key":"bibr70-7750.2010.09027","first-page":"308","volume":"8","author":"Schwartz HJ","year":"1986","journal-title":"Immunol Allergy Pract"},{"key":"bibr71-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90031-X"},{"key":"bibr72-7750.2010.09027","first-page":"233","volume":"65","author":"Sokol WN","year":"1990","journal-title":"Ann Allergy"},{"key":"bibr73-7750.2010.09027","first-page":"281","volume":"56","author":"Simon RA","year":"1986","journal-title":"Ann Allergy"},{"key":"bibr74-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1989.tb03120.x"},{"key":"bibr75-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2004.08.001"},{"key":"bibr76-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200124040-00001"},{"key":"bibr77-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.9.856.36106"},{"key":"bibr78-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1542\/peds.68.3.416"},{"key":"bibr79-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6181.14"},{"key":"bibr80-7750.2010.09027","first-page":"135","volume":"45","author":"Hill EM","year":"1988","journal-title":"Am J Hosp Pharm"},{"key":"bibr81-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-2-206"},{"key":"bibr82-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80617-2"},{"key":"bibr83-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92456-6"},{"key":"bibr84-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90920-1"},{"key":"bibr85-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(86)72715-1"},{"key":"bibr86-7750.2010.09027","first-page":"438","volume":"13","author":"Gulya AJ","year":"1992","journal-title":"Am J Otol"},{"key":"bibr87-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2154-b"},{"key":"bibr88-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90036-6"},{"key":"bibr89-7750.2010.09027","first-page":"77","volume":"10","author":"Gordon H","year":"1972","journal-title":"Cutis"},{"key":"bibr90-7750.2010.09027","first-page":"24","volume":"102","author":"Birbeck J","year":"1989","journal-title":"N Z Med J"},{"key":"bibr91-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2002.1542"},{"key":"bibr92-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/000992289203100703"},{"key":"bibr93-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1080\/15287397609529447"},{"key":"bibr94-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90254-A"},{"key":"bibr95-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268411"},{"key":"bibr96-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600520219"},{"key":"bibr97-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197808102990623"},{"key":"bibr98-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612183152515"},{"key":"bibr99-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348021"},{"key":"bibr100-7750.2010.09027","first-page":"831","year":"1979","journal-title":"Lancet"},{"key":"bibr101-7750.2010.09027","first-page":"460","volume":"53","author":"Gundend-Hower E","year":"1970","journal-title":"Am J Gastroenterol"},{"key":"bibr102-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03889.x"},{"key":"bibr103-7750.2010.09027","first-page":"200","volume":"6","author":"Huriez C","year":"1966","journal-title":"Rev Fr Allergy"},{"key":"bibr104-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1978.tb03719.x"},{"key":"bibr105-7750.2010.09027","first-page":"49","volume":"1","author":"Fisher AA","year":"1982","journal-title":"Semin Dermatol"},{"key":"bibr106-7750.2010.09027","first-page":"327","volume":"55","author":"Fisher AA","year":"1995","journal-title":"Cutis"},{"key":"bibr107-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70080-5"},{"key":"bibr108-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/9.1.40"},{"key":"bibr109-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G083"},{"key":"bibr110-7750.2010.09027","volume-title":"The Merck index\u2014an encyclopedia of chemicals, drugs, and biological","author":"Budavari S","year":"1989"},{"key":"bibr111-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000134831.40466.39"},{"key":"bibr112-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1007\/BF00717993"},{"key":"bibr113-7750.2010.09027","first-page":"877","volume":"93","author":"Martin G","year":"1978","journal-title":"J Pediatr"},{"key":"bibr114-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81183-4"},{"key":"bibr115-7750.2010.09027","first-page":"365","volume":"5","year":"1974","journal-title":"WHO Food Additives Serv"},{"key":"bibr116-7750.2010.09027","first-page":"163","volume":"74","author":"Patterson DL","year":"1995","journal-title":"Ann Allergy Asthma Immunol"},{"key":"bibr117-7750.2010.09027","first-page":"333","volume":"24","author":"Beaudoin E","year":"1992","journal-title":"Allergie Immunol"},{"key":"bibr118-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1159\/000070958"},{"key":"bibr119-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92815-5"},{"key":"bibr120-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/014107688507800415"},{"key":"bibr121-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(99)00158-1"},{"key":"bibr122-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00110-4"},{"key":"bibr123-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00325.x"},{"key":"bibr124-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00370.x"},{"key":"bibr125-7750.2010.09027","first-page":"2210","volume":"115","author":"Andersen HL","year":"1993","journal-title":"Ugeskr Laeger"},{"key":"bibr126-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013003318"},{"key":"bibr127-7750.2010.09027","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90709-2"}],"container-title":["Journal of Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2010.09027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.2310\/7750.2010.09027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.2310\/7750.2010.09027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:48:39Z","timestamp":1777391319000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.2310\/7750.2010.09027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.2310\/7750.2010.09027"],"URL":"https:\/\/doi.org\/10.2310\/7750.2010.09027","relation":{},"ISSN":["1203-4754","1615-7109"],"issn-type":[{"value":"1203-4754","type":"print"},{"value":"1615-7109","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}