{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:45:23Z","timestamp":1789969523740,"version":"4.0.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Med Surg"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pemphigus is an autoimmune blistering disease mediated by circulating IgG autoantibodies directed against desmogleins 3 and\/or 1. As pemphigus is a T cell\u2013mediated disease, one may assume that genetically determined disregulation of costimulatory signal may be involved in its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of the present study was to evaluate the relationship between polymorphisms in genes encoding costimulatory receptors, CTLA4 and ICOS, and pemphigus in the Polish population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study included 54 patients with pemphigus: 40 with pemphigus vulgaris (PV) and 14 with pemphigus foliaceus (PF). Additionally, 176 healthy unrelated blood donors served as controls. +49A\/G CTLA4 and IVS1+173 ICOS polymorphisms were identified using a modified polymerase chain reaction\u2013restriction fragment-length polymorphism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Analysis of the frequency of genotypes and alleles of +49A\/G CTLA4 gene polymorphism showed no statistically significant differences between the PV and PF patients and the controls. The distribution of genotypes in IVS1+173 ICOS polymorphisms was significantly different in both PV ( p &lt; .01) and PF ( p = .0004) patients when compared to controls. The carriers of the allele C were more frequent in PV or PF in comparison with the control group ( p &lt; .001 for both groups).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results suggest that genetically determined abnormal function of costimulatory receptors in T cells may be associated with the pathogenesis of pemphigus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2310\/7750.2010.09061","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T15:01:24Z","timestamp":1426086084000},"page":"291-297","source":"Crossref","is-referenced-by-count":10,"title":["ICOS Gene Polymorphism May Be Associated with Pemphigus"],"prefix":"10.1177","volume":"14","author":[{"given":"Joanna","family":"Narbutt","sequence":"first","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Lesiak","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela","family":"Klich","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta Dorota","family":"Torzecka","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sysa-Jedrzejowska","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"M\u0142ynarski","sequence":"additional","affiliation":[{"name":"From the Departments of Dermatology and Pediatrics and Laboratory of Immunodermatology, Medical University of Lodz, Lodz, 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